HISTOLOGIC GROWTH-PATTERN OF HEPATOCELLULAR-CARCINOMA - RELATIONSHIP TO ORCEIN(HEPATITIS-B SURFACE ANTIGEN)-POSITIVE CELLS IN CANCER-TISSUE
HISTOLOGIC GROWTH-PATTERN OF HEPATOCELLULAR-CARCINOMA - RELATIONSHIP TO ORCEIN(HEPATITIS-B SURFACE ANTIGEN)-POSITIVE CELLS IN CANCER-TISSUE
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DOI：
10.1016/s0046-8177(82)80272-4
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发表时间：
1982-01-01
期刊：
影响因子：
3.3
通讯作者：
OKUDA, K
中科院分区：
文献类型：
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作者：
NAKASHIMA, T;KOJIRO, M;OKUDA, K
在60例肝细胞癌患者中研究了肿瘤-非肿瘤边界肿瘤生长的组织学模式。三种生长模式，任意描述为正弦曲线，替代和封装，被区分开来。在肝细胞索之间的窦状隙中生长的癌细胞（正弦模式）是间变性的;那些以膨胀方式生长并获得纤维囊（包囊模式）的癌细胞分化最多;而那些生长到肝细胞索中并取代它们（替代模式）的癌细胞分化到中等程度。肿瘤的组织学生长方式与大体形态特征之间存在一定的关系。60例中20例血清HBsAg阳性，肝组织中也有绿脓菌素阳性细胞。Orcein阳性细胞多见于肿瘤与实质交界处。3例癌组织中存在HBsAg作为orcein阳性包涵体的细胞。当对这些区域进行连续切片并用苏木精、伊红和地衣红交替染色时，发现这些细胞是与癌细胞混合的肝细胞。这种现象与肿瘤细胞的生长方式有关。转移灶未见orcein阳性细胞。
The histologic pattern of tumor growth at tumor-nontumor boundaries was studied in 60 [human] livers bearing hepatocellular carcinoma. Three growth patterns, arbitrarily described as sinusoidal, replacing and encapsulated, were distinguished. Cancer cells growing in the sinusoids between liver cell cords (sinusoidal pattern) were anaplastic; those growing in an expansile fashion and acquiring a fibrous capsule (encapsulated pattern) were most differentiated; and those growing into the cord of liver cells and replacing them (replacing pattern) were differentiated to an intermediate degree. There was a certain relationship between the histologic growth patterns and gross morphologic features of the tumors. Test results for 20 of the 60 cases were positive for serum hepatitis B surface antigen (HBsAg) and the livers also contained orcein-positive cells. Orcein-positive cells were frequently seen at the border between tumor and parenchyma. Cells containing HBsAg as an orcein-positive inclusion were present in cancer tissue in 3 cases. When serial sections were made for such areas and stained alternately with hematoxylin and eosin and orcein, it was found that these cells were hepatocytes blended with cancer cells. This phenomenon was related to the growth pattern of tumor cells. Orcein-positive cells were never found in metastatic lesions.