14-3-3 proteins: a number of functions for a numbered protein.
14-3-3 proteins: a number of functions for a numbered protein.
复制标题
DOI：
10.1126/stke.2962005re10
复制
发表时间：
2005-08-09
期刊：
影响因子：
--
通讯作者：
Moorhead, Greg B G
中科院分区：
文献类型：
--
作者：
Bridges, Dave;Moorhead, Greg B G
许多信号转导事件是由蛋白质的特异性相互作用通过离散的磷酸肽结合基序介导的。尽管现在已知有几个磷酸特异性结合结构域，但14-3- 3是第一个被识别出与离散的磷酸丝氨酸或磷酸苏氨酸基序特异性结合的蛋白质。14-3-3蛋白是一个广泛表达的家族，仅是真核生物蛋白，具有大量的结合伴侣。因此，14-3-3s调节一个巨大而多样的细胞过程组。14-3-3蛋白对其靶标的影响可以使用三个类别来广泛定义：（i）构象变化;（ii）序列特异性或结构蛋白特征的物理闭塞;和（iii）支架。这篇综述将描述14-3-3蛋白质的知识现状，突出几个重要的进展，并试图提供一个框架，通过它可以理解14-3-3功能。
Many signal transduction events are orchestrated by specific interactions of proteins mediated through discrete phosphopeptide-binding motifs. Although several phosphospecific-binding domains are now known, 14-3-3s were the first proteins recognized to specifically bind a discrete phosphoserine or phosphothreonine motif. The 14-3-3 proteins are a family of ubiquitously expressed, exclusively eukaryotic proteins with an astonishingly large number of binding partners. Consequently, 14-3-3s modulate an enormous and diverse group of cellular processes. The effects of 14-3-3 proteins on their targets can be broadly defined using three categories: (i) conformational change; (ii) physical occlusion of sequence-specific or structural protein features; and (iii) scaffolding. This review will describe the current state of knowledge on 14-3-3 proteins, highlighting several important advances, and will attempt to provide a framework by which 14-3-3 functions can be understood.