TNF-alpha-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis.
TNF-alpha-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis.
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DOI：
10.1016/j.jneuroim.2010.05.003
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发表时间：
2010-07-27
影响因子：
3.3
通讯作者：
Klein RS
中科院分区：
文献类型：
--
作者：
Zhang B;Patel J;Croyle M;Diamond MS;Klein RS
The chemokine CXCL10 exerts antiviral effects within the central nervous system (CNS) through the recruitment of virus-specific T cells. However, elevated levels of CXCL10 may induce neuronal apoptosis given its receptor, CXCR3, is expressed by neurons. Using a murine model of West Nile virus (WNV) encephalitis, we determined that WNV-infected neurons express TNF-α, which down-regulates neuronal CXCR3 expression via signaling through TNFR1. Down-regulation of neuronal CXCR3 decreased CXCL10-mediated calcium transients and delayed Caspase 3 activation. Loss of CXCR3 activation, via CXCR3-deficiency or pretreatment with TNF-α prevented neuronal apoptosis during in vitro WNV infection. These results suggest that neuronal TNF-α expression during WNV encephalitis may be an adaptive response to diminish CXCL10-induced death.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
3.7
作者：
Feldman, ED;Weinreich, DM;Alexander, HR
通讯作者：
Alexander, HR
DOI：
10.1097/01.wcb.0000090080.64176.44
发表时间：
2003-10-01
影响因子：
6.3
作者：
Boche, D;Cunningham, C;Perry, VH
通讯作者：
Perry, VH
影响因子：
16.2
作者：
CHENG, B;CHRISTAKOS, S;MATTSON, MP
通讯作者：
MATTSON, MP
DOI：
10.1196/annals.1344.022
发表时间：
2005-01-01
期刊：
NEUROPROTECTIVE AGENTS
影响因子：
--
作者：
Bachis, A;Mocchetti, I
通讯作者：
Mocchetti, I