Adiponectin in cardiovascular inflammation and obesity.
Adiponectin in cardiovascular inflammation and obesity.
复制标题
DOI：
10.4061/2011/376909
复制
发表时间：
2011
影响因子：
2
通讯作者：
Sam F
中科院分区：
文献类型：
--
作者：
Aprahamian TR;Sam F
众所周知，炎症在心血管疾病的发生和发展中起着关键作用。越来越明显的是，肥胖与许多促炎性和肥胖相关的心血管疾病有关（例如，代谢综合征、急性冠状动脉综合征和充血性心力衰竭）。已经观察到脂肪因子在全身和局部炎症中发挥越来越大的作用。因此，脂肪组织可能在几种疾病类型的发病机制中具有比以前认为的更重要的作用。本文综述了脂联素作为一种免疫调节因子的作用，以及它与心血管和自身免疫性疾病相关炎症的关系。
Inflammation is widely known to play a key role in the development and progression of cardiovascular diseases. It is becoming increasingly evident that obesity is linked to many proinflammatory and obesity-associated cardiovascular conditions (e.g., metabolic syndrome, acute coronary syndrome, and congestive heart failure). It has been observed that adipokines play an increasingly large role in systemic and local inflammation. Therefore, adipose tissue may have a more important role than previously thought in the pathogenesis of several disease types. This review explores the recently described role of adiponectin as an immunomodulatory factor and how it intersects with the inflammation associated with both cardiovascular and autoimmune pathologies.