Psychological stress impairs hepatic blood flow via central CRF receptors in mice
Psychological stress impairs hepatic blood flow via central CRF receptors in mice
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DOI：
10.1016/j.lfs.2004.08.032
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发表时间：
2005-02-25
期刊：
影响因子：
6.1
通讯作者：
Kubo, C
中科院分区：
文献类型：
--
作者：
Chida, Y;Sudo, N;Kubo, C
一些先前的工作已经进一步扩展了“脑-肠轴”，即肠道和大脑功能之间的双向相互作用，成为大脑与肝脏的关系。然而，由于尚未建立合适的动物模型，脑-肝关系的所有细节尚未完全了解。在这里，我们开发了一种新的动物模型，其中清醒小鼠的肝血流量可以实时测量。此外，使用该模型，我们还证明，暴露于心理应激大大减少肝血流量通过中央CRF受体。因此，这个新的模型被认为是一个有用的和有前途的工具，阐明情绪因素对肝功能的确切影响。(C)2004年爱思唯尔公司All rights reserved.
Some previous works have further expanded the 'Brain-Gut axis', that is a bi-directional interaction between the gut and brain function, into a relationship of the brain with the liver. However, all the details of such brain-liver relationship were not fully understood because appropriate animal models had not been established yet. Here we developed a novel animal model, in which hepatic blood flow of conscious mice could be measured in real-time. In addition, using this model, we also demonstrated that exposure to psychological stress considerably reduced hepatic blood flow via central CRF receptors. Thus, this new model is considered to be a useful and promising tool for elucidating the precise effects of emotional factors on liver function. (C) 2004 Elsevier Inc. All rights reserved.