Ventral pallidal neurons code incentive motivation:: amplification by mesolimbic sensitization and amphetamine
Ventral pallidal neurons code incentive motivation:: amplification by mesolimbic sensitization and amphetamine
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DOI：
10.1111/j.1460-9568.2005.04411.x
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发表时间：
2005-11-01
影响因子：
3.4
通讯作者：
Aldridge, JW
中科院分区：
文献类型：
--
作者：
Tindell, AJ;Berridge, KC;Aldridge, JW
腹侧苍白球神经元对奖赏及其预测线索的反应。我们测试了中脑边缘激活对神经奖励编码的影响。大鼠了解到巴甫洛夫条件刺激（CS+1音）预测第二个条件刺激（CS+2馈线点击），然后是非条件刺激（UCS蔗糖奖励）。一些大鼠在训练后对安非他明过敏。腹侧苍白球神经元对刺激的电生理活动随后在媒介物或急性安非他明注射的影响下被记录。致敏和急性安非他明增加腹侧苍白球放电在CS+2（人口代码和率代码）。CS+1时无变化，UCS变化极小。与一个新的“配置文件分析”，我们表明，由致敏/安非他明的mesolimbic激活逐步转移神经元放电曲线远离预测信号编码（最大在CS+1）和激励编码（最大在CS+2），而不改变享乐的影响编码（最大在UCS）。这种模式表明，中脑边缘激活特别放大了CS+预测信息的动机转化为腹侧苍白球神经元编码的激励显着性。我们的研究结果支持激励敏感化的预测，并建议为什么线索时间接近药物介绍可能会沉淀线索触发人类成瘾者复发。
Neurons in ventral pallidum fire to reward and its predictive cues. We tested mesolimbic activation effects on neural reward coding. Rats learned that a Pavlovian conditioned stimulus (CS+1 tone) predicted a second conditioned stimulus (CS+2 feeder click) followed by an unconditioned stimulus (UCS sucrose reward). Some rats were sensitized to amphetamine after training. Electrophysiological activity of ventral pallidal neurons to stimuli was later recorded under the influence of vehicle or acute amphetamine injection. Both sensitization and acute amphetamine increased ventral pallidum firing at CS+2 (population code and rate code). There were no changes at CS+1 and minimal changes to UCS. With a new 'Profile Analysis', we show that mesolimbic activation by sensitization/amphetamine incrementally shifted neuronal firing profiles away from prediction signal coding (maximal at CS+1) and toward incentive coding (maximal at CS+2), without changing hedonic impact coding (maximal at UCS). This pattern suggests mesolimbic activation specifically amplifies a motivational transform of CS+ predictive information into incentive salience coded by ventral pallidal neurons. Our results support incentive-sensitization predictions and suggest why cues temporally proximal to drug presentation may precipitate cue-triggered relapse in human addicts.