Coping with emotions past: the neural bases of regulating affect associated with negative autobiographical memories.
Coping with emotions past: the neural bases of regulating affect associated with negative autobiographical memories.
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DOI：
10.1016/j.biopsych.2008.10.019
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发表时间：
2009-03-01
影响因子：
10.6
通讯作者：
Ochsner, Kevin
中科院分区：
文献类型：
--
作者：
Kross, Ethan;Davidson, Matthew;Weber, Jochen;Ochsner, Kevin
关键词：
尽管在不沉思的情况下适应性地反思负面自传体经历的能力对于心理健康至关重要，但据我们所知，还没有研究直接检查这一过程背后的神经系统。使用功能磁共振成像 (fMRI) 扫描 16 名参与者，因为他们使用旨在促进（感觉策略）而不是破坏（分析和接受策略）沉思的认知策略来关注负面自传体记忆。获得了两项重要发现。首先，与之前使用基于图像的刺激的情绪调节研究一致，在所有三种策略的实施过程中观察到左前额叶活动。其次，涉及自我参照处理和情感的区域网络（包括膝下前扣带皮层和内侧前额叶皮层）的活动对感觉策略的反应最高，对接受策略的反应最低。这种激活模式反映了参与者在参与每种策略时的负面影响的自我报告。这些发现揭示了区分消极自传记忆的适应性和适应不良形式的大脑区域，并为利用功能磁共振成像探索情绪调节的神经基础提供了一种新颖的、生态上有效的途径。
Although the ability to adaptively reflect on negative autobiographical experiences without ruminating is critical to mental health, to our knowledge no research has directly examined the neural systems underlying this process. Sixteen participants were scanned using functional magnetic resonance imaging (fMRI) as they focused on negative autobiographical memories using cognitive strategies designed to facilitate (feel strategy) versus undermine (analyze and accept strategies) rumination. Two key findings were obtained. First, consistent with prior emotion regulation research using image-based stimuli, left prefrontal activity was observed during the implementation of all three strategies. Second, activity in a network of regions involved in self-referential processing and emotion, including subgenual anterior cingulate cortex and medial prefrontal cortex, was highest in response to the feel strategy and lowest for the accept strategy. This pattern of activation mirrored participants’ self-reports of negative affect when engaging in each strategy. These findings shed light on the brain regions that distinguish adaptive versus maladaptive forms of reflecting on negative autobiographical memories and offer a novel, ecologically valid route to exploring the neural bases of emotion regulation using fMRI.
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