Treatment of Metastatic Trophoblastic Disease with Poor Prognosis
Treatment of Metastatic Trophoblastic Disease with Poor Prognosis
复制标题
预后不良的转移性滋养细胞疾病的治疗
作者：
E. Surwit;C. Hammond
本文介绍了1968年至1978年间杜克大学医学中心（东南地区滋养细胞疾病中心）医生治疗的预后不良的妊娠滋养细胞疾病的51例患者。72%（51例患者中的37例）的疾病目前处于缓解期（8个月至10年）。治疗主要是通过多药化疗，并在选定的患者中进行连续手术和放射治疗。在该中心治疗前化疗不成功，从前期怀孕到治疗的间隔时间延长，以及肝转移预示着这些患者的预后更差。
Fifty-one patients are presented who were treated for poor-prognosis gestational trophoblastic disease by physicians at Duke University Medical Center (Southeastern Regional Trophoblastic Disease Center) between 1968 and 1978. Disease in 72% (37 of 51 patients) is currently in remission (8 months to 10 years). Treatment was primarily by multi-agent chemotherapy, with adjunctive surgery and radiation therapy in selected patients. Unsuccessful chemotherapy prior to treatment at this center, a prolonged interval from the antecedent pregnancy to treatment, and liver metastases portended a worse prognosis in these patients.