Long-term effects of prenatal morphine exposure on maternal behaviors differ from the effects of direct chronic morphine treatment.
Long-term effects of prenatal morphine exposure on maternal behaviors differ from the effects of direct chronic morphine treatment.
复制标题
产前吗啡暴露对母亲行为的长期影响不同于直接长期吗啡治疗的影响。
DOI：
10.1002/dev.10141
复制
发表时间：
2003
影响因子：
2.2
通讯作者：
Vathy,Ilona
中科院分区：
文献类型：
--
作者：
Slamberová,Romana;Bar,Noffar;Vathy,Ilona
先前的研究表明，长期吗啡治疗怀孕大鼠会改变母亲的行为。其他研究表明，产前暴露于吗啡的长期影响，包括成年女性生殖行为的变化。本研究探讨了产前吗啡暴露对各种母亲行为的影响，如护理，母亲的活动，非母亲的活动，和小狗检索。产前吗啡暴露增加主动和减少被动护理。在母体活动方面没有差异，例如在巢穴中的存在、与幼仔的接触、幼仔的梳理和/或巢刨屑的操纵。在取回测试中，产前暴露于吗啡的母亲在携带第一只幼崽、将第一只幼崽取回巢以及将所有幼崽送回巢方面比产前暴露于盐水的母亲更快。母亲和非母亲的活动也受到影响的光：暗周期。所有暴露于盐水和吗啡的母亲在光照期间比黑暗期间更多地哺乳，更经常在巢中，并且更经常与超过一半的幼崽接触。另一方面，非母亲的活动增加在黑暗的会议：母亲照顾自己（梳洗，吃）更多，并显示更多的饲养和嗅探。无论产前药物暴露如何，母亲在光照期间都花更多的时间闭眼休息。本研究表明，吗啡对母亲行为的影响是不同的，在成人和产前暴露的母亲。虽然直接吗啡治疗损害了母亲的行为，产前吗啡暴露有相反的效果。© 2003威利期刊公司Dev Psychobiol 43：281-289，2003.
Previous studies have demonstrated that chronic morphine treatment of pregnant rats alters maternal behavior. Other studies have shown long‐term effects of prenatal exposure to morphine, including changes in reproductive behavior in adult females. The present study investigated the effects of prenatal morphine exposure on a variety of maternal behaviors such as nursing, maternal activities, nonmaternal activities, and pup retrieval. Prenatal morphine exposure increased active and decreased passive nursing. There were no differences in maternal activities such as presence in the nest, contact with pups, grooming of pups, and/or manipulation of nest shavings. In the retrieval test, prenatally morphine‐exposed mothers were faster in carrying the first pup, retrieving the first pup back to the nest, and returning all pups to the nest than prenatally saline‐exposed mothers. Maternal and nonmaternal activities also were affected by the light:dark cycle. All saline‐ and morphine‐exposed mothers nursed more, were more often in the nest, and more often in contact with greater than half of their litter during the light than the dark sessions. On the other hand, nonmaternal activities increased during the dark sessions: Mothers cared for themselves (groomed, ate) more and displayed more rearing and sniffing. Mothers spent more time resting with their eyes closed during the light sessions regardless of prenatal drug exposure. The present study demonstrated that the effect of morphine on maternal behavior is different in adult exposed and prenatally exposed mothers. While direct morphine treatment impaired maternal behaviors, prenatal morphine exposure has the opposite effect. © 2003 Wiley Periodicals, Inc. Dev Psychobiol 43: 281–289, 2003.
登录
查看更多内容
阿片拮抗剂减少产妇的胎盘吞食和幼崽清洁
影响因子：
3.6
作者：
A. D. Mayer;P. L. Faris;B. Komisaruk;J. Rosenblatt
通讯作者：
J. Rosenblatt
大鼠母幼互动的长期研究：婴儿刺激、昼夜节律和幼崽成熟的影响。
影响因子：
1.3
作者：
M. H. Lee;D. Williams
通讯作者：
D. Williams
12 – 苯二氮卓类药物和发育中的神经系统：实验室结果和临床意义
DOI：
--
发表时间：
1992
期刊：
影响因子：
--
作者：
C. Kellogg
通讯作者：
C. Kellogg
激素中β-促脂蛋白的内啡肽残基是否会增强生殖功能？
影响因子：
9.8
作者：
C. D. Kimball
通讯作者：
C. D. Kimball
分娩前后内侧视前μ阿片受体密度的激素调节。
影响因子：
4.1
作者：
HammerJr,RP;Mateo,AR;Bridges,RS
通讯作者：
Bridges,RS