Release of neurotransmitters in the monkey frontal cortex is related to level of attention
Release of neurotransmitters in the monkey frontal cortex is related to level of attention
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DOI：
10.1046/j.1440-1819.2002.00977.x
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发表时间：
2002-06-01
影响因子：
11.9
通讯作者：
Hikosaka, K
中科院分区：
文献类型：
--
作者：
Kodama, T;Honda, Y;Hikosaka, K
据报道，注意力由单胺、乙酰胆碱和氨基酸系统维持。研究了在安静觉醒(QW)和两个觉醒状态(AW)三个阶段中，这些神经递质释放的变化，这三个阶段是从不同来源激活的。AW组去甲肾上腺素释放显著高于QW组。相反，在这三个阶段中，释放的乙酰胆碱和5-羟色胺水平没有显著变化。有趣的观察是在两种AW状态下谷氨酸和多巴胺释放的增加是分离的。这些结果表明，注意水平与去甲肾上腺素的释放量有关，注意质量与多巴胺和谷氨酸的释放量之间的相互作用有关。
Attention is reported to be maintained by monoamines, acetylcholine and amino acids systems. Changes in the releases of these neurotransmitters during the three stages comprising quiet wake (QW) and two arousal states (AW), which are activated from different sources, were investigated. Norepinephrine releases during AW were significantly higher than that during QW. Conversely, the levels of acetylcholine and serotonin that were released did not change significantly among these three stages. The interesting observation was the dissociation of the increase between glutamate and dopamine releases in the two AW states. These results indicate that attention level is related to the amount of norepinephrine release, and that attention quality is related to the interaction between dopamine and glutamate releases.