New alleles of Notch draw a blueprint for multifunctionality
New alleles of Notch draw a blueprint for multifunctionality
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DOI：
10.1016/s0168-9525(01)02635-x
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发表时间：
2002-04-01
影响因子：
11.4
通讯作者：
Arias, AM
中科院分区：
文献类型：
--
作者：
Arias, AM
果蝇Notch蛋白是介导发育过程中细胞命运分配的重要且可能是普遍功能的受体家族之一。Notch被其配体Delta激活，导致受体的胞内结构域裂解。该结构域定位到细胞核，在那里它与转录因子无毛抑制因子结合以调节基因表达。在最近的一份报告中，Ramain，Heitzler及其同事揭示了第二个Notch信号传导活性的存在，该活性独立于无毛抑制因子，并可能用于将Notch活性与其他信号传导途径联系起来，特别是Wingless/Wnt信号传导。这种联系可能是一个核心要素，在许多过程中的细胞命运分配在发展过程中。
The Drosophila Notch protein is one of a family of receptors that mediate an essential and perhaps universal function in the assignation of cell fates during development. Activation of Notch by its ligand, Delta, leads to the cleavage of the intracellular domain of the receptor. This domain relocates to the nucleus, where it combines with the transcription factor Suppressor of Hairless to regulate gene expression. In a recent report, Ramain, Heitzler and colleagues reveal the existence of a second Notch signalling activity that is independent of Suppressor of Hairless and might be used to link Notch activity to that of other signalling pathways, most notably Wingless/Wnt signalling. This link might be a central element in many processes of cellfate assignation during development.