VIRULENCE OF RIMANTADINE-RESISTANT HUMAN INFLUENZA-A (H3N2) VIRUSES IN FERRETS
VIRULENCE OF RIMANTADINE-RESISTANT HUMAN INFLUENZA-A (H3N2) VIRUSES IN FERRETS
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DOI：
10.1093/infdis/164.5.969
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发表时间：
1991-11-01
影响因子：
6.4
通讯作者：
HAY, AJ
中科院分区：
文献类型：
--
作者：
SWEET, C;HAYDEN, FG;HAY, AJ
研究了金刚乙胺耐药突变对人H3N2病毒在雪貂体内毒力的影响。在M2序列的27、30和31三个不同位置上单氨基酸取代的耐药突变体及其相应的敏感野生型分离株的毒力相似，与三对病毒之间的毒力差异形成对比。这些数据提供了进一步的证据，证明在使用该药物治疗患者期间出现的金刚乙胺耐药病毒在其生长特征和毒性方面没有改变。
The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.