In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes
In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes
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DOI：
10.1016/j.phytochem.2009.10.020
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发表时间：
2010-02-01
期刊：
影响因子：
3.8
通讯作者：
Koenig, Gabriele M.
中科院分区：
文献类型：
--
作者：
Parys, Sabine;Kehraus, Stefan;Koenig, Gabriele M.
在一个专注于藻类酚的化学预防潜力的项目中，从棕色岩藻（Fucus vesiculosus L.）的乙醇提取物中获得了属于岩藻酚类的两种间苯三酚衍生物和已知的岩藻三酚A。化合物三岩藻二酚A和三岩藻三酚A分别由6个和7个间苯三酚单元组成。与单体间苯三酚相比，检测了化合物的癌症化学预防潜力。三岩藻二酚A、三岩藻三酚A以及岩藻三酚A被鉴定为强自由基清除剂，清除1，1-二苯基-2苦基肼基自由基（DPPH）的IC 50值在10.0-14.4 μ g/ml的范围内。在氧自由基吸收能力（CRAC）测定中，所有三种化合物都有效地清除过氧化氢自由基。此外，这些化合物显示出抑制细胞色素P450 1A活性的IC 50值在17.9-33 μ g/ml的范围内，和抑制芳香酶（Cyp 19）活性的IC 50值在1.2-5.6 μ g/ml的范围内。(C)2009爱思唯尔有限公司保留所有权利。
Within a project focusing on the chemopreventive potential of algal phenols, two phloroglucinol derivatives, belonging to the class of fucophlorethols, and the known fucotriphlorethol A were obtained from the ethanolic extract of the brown alga Fucus vesiculosus L. The compounds trifucodiphlorethol A and trifucotriphlorethol A are composed of six and seven units of phloroglucinol, respectively.The compounds were examined for their cancer chemopreventive potential, in comparison with the monomer phloroglucinol. Trifucodiphlorethol A, trifucotriphlorethol A as well as fucotriphlorethol A were identified as strong radical scavengers, with IC50 values for scavenging of 1,1-diphenyl-2 picrylhydrazyl radicals (DPPH) in the range of 10.0-14.4 mu g/ml. All three compounds potently scavenged peroxyl radicals in the oxygen radical absorbance capacity (CRAC) assay. In addition, the compounds were shown to inhibit cytochrome P450 1A activity with IC50 values in the range of 17.9-33 mu g/ml, and aromatase (Cyp19) activity with IC50 values in the range of 1.2-5.6 mu g/ml. (C) 2009 Elsevier Ltd. All rights reserved.