Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study
Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study
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DOI：
10.1007/s00535-004-1339-4
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发表时间：
2004-06-01
影响因子：
6.3
通讯作者：
Nagasako, K
中科院分区：
文献类型：
--
作者：
Kitajima, K;Fujimori, T;Nagasako, K
背景黏膜下浸润性结直肠癌（SICC）的黏膜下浸润深度（SM depth）被认为是预测淋巴结转移的重要指标。然而，没有全国性的报道阐明SM深度和淋巴结转移率之间的关系。我们的目的是探讨SICC中淋巴结转移与SM深度的相关性。方法. SM深度测量865 SICC手术切除在日本各地的六个机构。对于带蒂SICC，使用根据Haggitt分类的2级线作为基线，并测量从该基线到粘膜下层最深部分的SM深度。当侵犯的最深部分仅限于基线以上时，该病例被定义为头部侵犯。对于无蒂SICC，当可以识别粘膜肌层时，将粘膜肌层用作基线，从该线到浸润最深部分的垂直距离代表SM深度。当粘膜肌层由于癌性浸润而无法识别时，将SICC的浅表部分用作基线，并确定从该线到最深部分的垂直距离。结果有蒂型SICC头部浸润、茎部浸润伴SM深度者淋巴结转移率为0%
Background. Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the correlations between lymph node metastasis and SM depth in SICC. Methods. SM depth was measured for 865 SICCs that were surgically resected at six institutions throughout Japan. For pedunculated SICC, the level 2 line according to Haggitt's classification was used as baseline and the SM depth was measured from this baseline to the deepest portion in the submucosa. When the deepest portion of invasion was limited to above the baseline, the case was defined as a head invasion. For nonpedunculated SICC, when the muscularis mucosae could be identified, the muscularis mucosae was used as baseline and the vertical distance from this line to the deepest portion of invasion represented SM depth. When the muscularis mucosae could not be identified due to carcinomatous invasion, the superficial aspect of the SICC was used as baseline, and the vertical distance from this line to the deepest portion was determined. Results. For pedunculated SICC, rate of lymph node metastasis was 0% in head invasion cases and stalk invasion cases with SM depth