Study of the Usefulness of Bone Scan Index Calculated From 99m-Technetium-Hydroxymethylene Diphosphonate (99mTc-HMDP) Bone Scintigraphy for Bone Metastases from Prostate Cancer Using Deep Learning Algorithms
Study of the Usefulness of Bone Scan Index Calculated From 99m-Technetium-Hydroxymethylene Diphosphonate (99mTc-HMDP) Bone Scintigraphy for Bone Metastases from Prostate Cancer Using Deep Learning Algorithms
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DOI：
10.2174/1573405616666200528153453
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发表时间：
2021-01-01
影响因子：
1.4
通讯作者：
Kawabe, Joji
中科院分区：
文献类型：
--
作者：
Higashiyama, Shigeaki;Yoshida, Atsushi;Kawabe, Joji
背景资料：用~（99 m）锝-亚甲基二膦酸盐（Tc-99 m-MDP）骨显像计算骨密度指数（BSI），可作为骨转移的定量指标，用于骨转移的诊断、疗效评价和预后预测。然而，计算BSI的BONE NAVI仅支持使用Tc-99 m-MDP的骨扫描成像。目的：我们与东京农工大学合作开发了一种方法，使用深度学习算法计算骨扫描指数（BSI），使用（99 m）锝-羟基亚甲基二膦酸盐（Tc-99 m-HMDP）的骨扫描成像图像。我们使用了卷积神经网络（CNN），能够同时处理前后骨造影图像，称为CNNapis.Objectives：本研究的目的是调查由CN-Napis计算的BSI作为前列腺癌骨转移患者的骨成像和骨代谢生物标志物的有用性。方法：在我院，121例前列腺癌骨转移患者进行了Tc-99 m-HMDP骨显像检查，发现骨转移部位放射性同位素（RI）异常蓄积。同时进行血清前列腺特异性抗原（PSA）和碱性磷酸酶（ALP）的血液检查。通过CNNapis计算的BSI值用于量化转移性骨肿瘤的累及。计算BSI与PSA及ALP的相关性。根据BSI值将受试者分为四组（第1组，0至10）。
Background: BSI calculated from bone scintigraphy using (99m)technetium-methylene diphosphonate (Tc-99m-MDP) is used as a quantitative indicator of metastatic bone involvement in bone metastasis diagnosis, therapeutic effect assessment, and prognosis prediction. However, the BONE NAVI, which calculates BSI, only supports bone scintigraphy using Tc-99m-MDP.Aims: We developed a method in collaboration with the Tokyo University of Agriculture and Technology to calculate bone scan index (BSI) employing deep learning algorithms with bone scintigraphy images using (99m)Technetium-hydroxymethylene diphosphonate (Tc-99m-HMDP). We used a convolutional neural network (CNN), enabling the simultaneous processing of anterior and posterior bone scintigraphy images named CNNapis.Objectives: The purpose of this study is to investigate the usefulness of the BSI calculated by CN-Napis as bone imaging and bone metabolic biomarkers in patients with bone metastases from prostate cancer.Methods: At our hospital, 121 bone scintigraphy scans using Tc-99m-HMDP were performed and analyzed to examine bone metastases from prostate cancer, revealing the abnormal accumulation of radioisotope (RI) at bone metastasis sites. Blood tests for serum prostate-specific antigen (PSA) and alkaline phosphatase (ALP) were performed concurrently. BSI values calculated by CNNapis were used to quantify the metastatic bone tumor involvement. Correlations between BSI and PSA and between BSI and ALP were calculated. Subjects were divided into four groups by BSI values (Group 1, 0 to