Current advances in intratumoral androgen metabolism in castration-resistant prostate cancer.
Current advances in intratumoral androgen metabolism in castration-resistant prostate cancer.
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去势抵抗性前列腺癌瘤内雄激素代谢的最新进展。
DOI：
10.1097/med.0000000000000253
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tamae,Daniel
中科院分区：
文献类型：
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作者：
Penning,TrevorM;Tamae,Daniel
这些研究强调了瘤内雄激素生物合成在 mCRPC 肿瘤中发挥的重要作用。治疗意义包括抑制肿瘤中的 AKR1C3，这些肿瘤对醋酸阿比特龙或 Enza 等现有药物产生耐药性，以及 D4A 作为 mCRPC 治疗剂的潜在应用。
These studies highlight the significant role that intratumoral androgen biosynthesis plays in the mCRPC tumor. The therapeutic implications include the inhibition of AKR1C3 in tumors that become resistant to current drugs such as abiraterone acetate or Enza and the potential administration of D4A as an mCRPC therapeutic.