Picosecond pulse duration laser treatment for dermal melanocytosis in Asians : A retrospective review.
Picosecond pulse duration laser treatment for dermal melanocytosis in Asians : A retrospective review.
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皮秒脉冲持续激光治疗亚洲人真皮黑素细胞增多症：回顾性评论。
DOI：
10.5978/islsm.16-or-07
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
K. Kishi
中科院分区：
文献类型：
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作者：
T. Ohshiro;T. Ohshiro;K. Sasaki;K. Kishi
背景与目的：近年来，新型皮秒持续激光（ps-激光器）已被开发用于治疗多色和顽固性纹身，其安全性和有效性已得到报道。因此，我们假设ps激光可能是皮肤色素病变的一种替代治疗方法，并进行了回顾性评价ps激光的有效性和安全性。对象和方法：对10例皮肤色素病变患者（年龄4个月~ 52岁）进行回顾性摄影复习，其中太田痣6例，异位蒙古斑3例，蒙古斑1例。2014年4月至2015年12月，患者在Ohshiro诊所接受皮秒755 nm亚历山大激光（ps-Alex激光）和皮秒1064 nm Nd:YAG激光（ps-Nd:YAG激光）治疗（ps-Alex激光，7例；ps-Nd:YAG激光，3例，1 ~ 3次治疗）。改善以色素沉着清除率的百分比进行评估，将基线结果与最终治疗后3个月的结果进行比较，使用5类分级量表：差，0-24%；公平的,25 - 49%;好,50 - 74%;好,75 - 94%;完成，95-100%的改进。对不良事件也进行了评估。结果：10例患者均获得一般到优异的临床改善。ps-Alex激光治疗引起短暂性色素沉着，随后在3个月的随访中改善至完全消退。ps-Nd:YAG激光引起严重的短暂性红斑和肿胀，但没有炎症后色素沉着。结论：我们的研究结果表明，755 nm和1064 nm的ps激光治疗皮肤色素病变是有效的，并且不良事件最小。
Background and aims: Recently novel picosecond duration lasers (ps-lasers) have been developed for the treatment of multicolored and recalcitrant tattoos, and safety and efficacy have been reported. We therefore hypothesized that the ps-laser could be an alternative treatment for dermal pigmented lesions and performed a retrospective review to evaluate the efficacy and safety of the ps-laser. Subjects and methods: A retrospective photographic review of 10 patients with dermal pigmented lesions was performed (ages from 4 months to 52 yr), 6 nevus of Ota, 3 ectopic Mongolian spots and 1 Mongolian spots. The patients were treated in the Ohshiro Clinic with picosecond 755 nm alexandrite laser (ps-Alex laser) and picosecond 1064 nm Nd:YAG laser (ps-Nd:YAG laser) from April 2014 to December 2015 (ps-Alex laser, 7 patients; ps-Nd:YAG laser, 3 patients, 1 to 3 treatment sessions). Improvement was evaluated as percentage of pigmentation clearance comparing the baseline findings with those at 3 months after the final treatment using a five category grading scale: Poor, 0-24%; Fair, 25-49%; Good, 50-74%; Excellent, 75-94%; and Complete, 95-100% improvement. Adverse events were also assessed. Results: All ten patients obtained clinical improvement ranging from fair to excellent. Treatment with the ps-Alex laser caused transient hyperpigmentation followed by improvement to complete resolution at 3 months follow-up. The ps-Nd:YAG laser caused severe transient erythema and swelling but no post-inflammatory hyperpigmentation. Conclusions: Our results suggest that the 755 nm and 1064 nm ps-lasers are efficacious for the treatment of dermal pigment lesions, with minimum adverse events.