Therapeutic role of systematic retroperitoneal lymphadenectomy in endometrial cancer.
Therapeutic role of systematic retroperitoneal lymphadenectomy in endometrial cancer.
复制标题
系统性腹膜后淋巴结切除术在子宫内膜癌中的治疗作用。
DOI：
10.1684/bdc.2011.1536
复制
发表时间：
2012
影响因子：
1.2
通讯作者：
B. Kong
中科院分区：
文献类型：
--
作者：
Hui Zhang;L. Jia;Qing Zhang;Youzhong Zhang;Xingsheng Yang;B. Kong
目的
本研究的目的是评估系统性腹膜后淋巴结清扫术在子宫内膜癌患者中的治疗作用。
方法
从2003年12月至2008年12月，对349例在初次治疗时接受外科分期手术的合格患者进行了回顾性分析：系统性淋巴结切除术组（n = 246）和非淋巴结切除术组（n = 103）。采用Kaplan-Meier法和考克斯比例风险模型分析生存率。
结果
总体而言，与未接受淋巴结切除术的患者相比，接受淋巴结切除术的患者5年无病生存率（89.0% vs 80.7%，P = 0.019）和总生存率（92.8% vs 81.5%，P = 0.001）均有所改善。212例低危患者的总生存率与淋巴结切除术无关（93.1%对84.6%，P = 0.176）。然而，在137例中高危患者中发现了这种相关性（86.2% vs 73.3%，P = 0.021）。多因素考克斯回归分析显示FIGO分期（P = 0.037）和淋巴结清扫（P = 0.023）是影响总生存率的独立预后因素。
结论
系统性腹膜后淋巴结切除术对手术分期的子宫内膜癌患者的生存具有潜在的治疗作用。
OBJECTIVE
The purpose of this study was to evaluate the therapeutic role of systematic retroperitoneal lymphadenectomy in patients with endometrial cancer.
METHODS
From December 2003 to December 2008, 349 eligible patients who underwent surgical staging procedures at primary treatment were retrospectively analyzed: systematic lymphadenectomy group (n = 246) and no-lymphadenectomy group (n = 103). Survival was analyzed using Kaplan-Meier method and Cox proportional hazards model.
RESULTS
Overall, patients who underwent lymphadenectomy improved 5-year disease-free survival (89.0% versus 80.7%, P = 0.019) and overall survival (92.8% versus 81.5%, P = 0.001) compared to those who did not undergo lymphadenectomy. Overall survival was not related to lymphadenectomy in 212 low-risk patients (93.1% versus 84.6%, P = 0.176). However, this association was found in 137 patients with intermediate and high-risk (86.2% versus 73.3%, P = 0.021). Multivariate Cox regression analysis showed that FIGO stage (P = 0.037) and lymphadenectomy (P = 0.023) were independent prognostic factors for overall survival.
CONCLUSIONS
Systematic retroperitoneal lymphadenectomy has a potentially therapeutic role on survival in surgically staged patients with endometrial cancer.
日本子宫内膜癌的手术治疗现状：日本妇科肿瘤团体调查结果
DOI：
--
发表时间：
2007
期刊：
Gynecologic Oncology (in press)
影响因子：
--
作者：
Yoh Watanabe;Daisuke Aoki;(4 persons);Nobuo Yaegashi
通讯作者：
Nobuo Yaegashi
影响因子：
4.7
作者：
Yabushita, H;Shimazu, M;Kawai, M
通讯作者：
Kawai, M