The onset of angiogenesis in a multistep process of esophageal squamous cell carcinoma
The onset of angiogenesis in a multistep process of esophageal squamous cell carcinoma
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DOI：
10.2741/3495
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发表时间：
2009-01-01
影响因子：
3.1
通讯作者：
Imawari, Michio
中科院分区：
文献类型：
--
作者：
Kubota, Yutaro;Kaneko, Kazuhiro;Imawari, Michio
微血管密度 (MVD) 是食管鳞状细胞癌 (ESCC) 肿瘤分期和生存的极佳预测生物标志物。然而，在人食管鳞状上皮的恶性转化中，组织何时启动血管生成尚不清楚。为了研究 ESCC 多步进展过程中血管生成的发生，对正常上皮、非发育不良上皮的 Lugol 未染色病变 (LULs-NDE)、低度不典型增生 (LGD) 和高度不典型增生 (HGD) 样本进行 CD31、CD105 和血管内皮生长因子受体 2 (VEGFR-2) 的免疫组织化学染色。 LULs-NDE 和 LGD 之间 CD31 和 CD105 的平均 MVD 存在显着差异 (p
Microvessel density (MVD) is an excellent predictive biomarker regarding tumor stage and survival in esophageal squamous cell carcinomas (ESCCs). However, it is obscure when tissues initiate angiogenesis in the malignant transformation of human esophageal squamous epithelium. To investigate the onset of angiogenesis in the multistep progressive process of ESCCs, immunohistochemical staining for CD31, CD105, and vascular endothelial growth factor receptor 2 (VEGFR-2) was performed in normal epithelium, Lugol-unstained lesions with non-dysplastic epithelium (LULs-NDE), low-grade dysplasia (LGD), and high-grade dysplasia (HGD) samples. There were significant differences in the mean MVD for CD31 and CD105 between LULs-NDE and LGD (p