Cortical barrel field ablation and unconditioned whisking kinematics.
Cortical barrel field ablation and unconditioned whisking kinematics.
复制标题
皮质桶场消融和无条件搅拌运动学。
DOI：
10.1080/01421590120072213
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Zeigler,HP
中科院分区：
文献类型：
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作者：
Harvey,MA;Sachdev,RN;Zeigler,HP
“桶皮质”消融后的生物统计学的“探索性”搅拌的影响进行了研究，在三个头部固定的大鼠，以前持续单侧消融的左皮质“桶场”电生理控制下。一对双侧同源须（C-1，右，左）的无条件运动进行监测，光电，与其他晶须存在。完整侧和消融侧的拂动运动进行了分析，相对于运动学（延长幅度和速度），拂动频率和相位之间的关系，拂动运动的两侧的脸。组织学分析证实S-1“桶状皮质”完全清除。在正常动物中，拂动运动具有特征性的节奏（6-9 Hz），并且面部两侧的延长往往是同步的并且具有非常相似的幅度。在损伤的动物，搅拌频率不变，搅拌运动保持双边同步。然而，术后多个月左右胡须运动幅度存在显著差异。我们的研究结果表明，赤字触须介导的触觉歧视报告后，“桶”场消融可能反映了动物的能力，以调节搅拌参数的两侧的脸，以满足功能要求的歧视搅拌任务的损害。在单侧桶场消融后观察到的对搅拌幅度的影响与其中搅拌中央模式发生器的活动通过下降输入来调制以实现搅拌运动参数的感觉运动控制的模型一致。
The effects of “barrel cortex” ablation upon the biometrics of “exploratory” whisking were examined in three head-fixed rats which had previously sustained unilateral ablation of the left cortical “barrel field” under electrophysiological control. Unconditioned movements of a pair of bilaterally homologous whiskers (C-1, Right, Left) were monitored, optoelectronically, with other whiskers present. Whisking movements on the intact and ablated side were analyzed with respect to kinematics (protraction amplitude and velocity) whisking frequency and phase relationships between whisking movement on the two sides of the face. Histological analysis confirmed complete removal of S-1 “barrel cortex”. In normal animals whisking movements have a characteristic rhythm (6-9 Hz), and protractions on the two sides of the face tend to be both synchronous and of very similar amplitudes. In the lesioned animals, whisking frequency was unchanged and whisking movements remained bilaterally synchronous. However, there was a significant difference between the amplitude of Right and Left whisker movements which was evident many months postoperatively. Our results suggest that the deficits in vibrissa-mediated tactile discrimination reported after “barrel” field ablation may reflect an impairment in the animal's ability to modulate whisking parameters on the two sides of the face to meet the functional requirements of a discriminative whisking task. The effects upon whisking amplitude seen after unilateral barrel field ablation are consistent with a model in which the activity of a whisking Central Pattern Generator is modulated by descending inputs to achieve sensorimotor control of whisking movement parameters.