PATTERN REGULATION IN EPIMORPHIC FIELDS
PATTERN REGULATION IN EPIMORPHIC FIELDS
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DOI：
10.1126/science.948762
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
BRYANT, SV
中科院分区：
文献类型：
--
作者：
FRENCH, V;BRYANT, PJ;BRYANT, SV
描述了一种用二维极坐标表示位置信息的外射场中图案调节的形式模型。表形视野内的细胞似乎遵循两个简单的规则：最短嵌入规则和完整圆规则，对于这两个规则，都有直接的实验证据。作为这两条规则的直接结果，我们有可能理解外态场的大量不同行为。该模型提供了一个查看实验胚胎学的许多结果的背景。尽管讨论仅限于蟑螂腿、果蝇的想象盘以及再生和发育的两栖动物肢体，但该模型可以解释这种进化多样性动物的调节行为这一事实表明，它可能对表形领域具有普遍适用性。该模型所做的预测可能使评估其对其他开发系统的适用性成为可能，并研究其中涉及的细胞机制。
A formal model for pattern regulation in epimorphic fields in which positional information is specified in terms of polar coordinates in 2 dimensions is described. Cells within epimorphic fields appear to behave according to 2 simple rules: the shortest intercalation rule and the complete circle rule, for both of which there is direct experimental evidence. It is possible to understand a large number of different behaviors of epimorphic fields as a straightforward consequence of these 2 rules. The model provides a context in which to view many of the results of experimental embryology. Although discussion was confined to cockroach legs, the imaginal disks of Drosophila and regenerating and developing amphibian limbs, the fact that the model can explain regulative behavior in such evolutionarily diverse animals suggests that it may have general applicability to epimorphic fields. The predictions which the model makes may make it possible to assess its applicability to other developing systems, and to investigate the cellular mechanisms involved.