Surface modification and functionalization of nanoscale metal-organic frameworks for controlled release and luminescence sensing
Surface modification and functionalization of nanoscale metal-organic frameworks for controlled release and luminescence sensing
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DOI：
10.1021/ja073506r
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发表时间：
2007-08-15
影响因子：
15
通讯作者：
Lin, Wenbin
中科院分区：
文献类型：
--
作者：
Rieter, William J.;Taylor, Kathryn M. L.;Lin, Wenbin
在本文中，我们描述了一种通用的方法来合成一类新的纳米复合材料与纳米金属有机框架（NMOF）的核心和二氧化硅壳。采用溶胶-凝胶法将不同厚度的二氧化硅壳层沉积在用聚乙烯吡咯烷酮（PVP）表面改性的NMOFs上。纳米复合材料的NMOF核可以在低pH下完全去除（通过溶解），以提供具有不同厚度和纵横比的中空二氧化硅壳。我们还表明，这种纳米复合材料的二氧化硅壳显着稳定的NMOF核心对溶解，从而证明了控制金属成分从这种二氧化硅涂覆的NMOF的释放的能力。硅壳进一步官能化的甲硅烷基化的Tb-EDTA单酰胺衍生物的发光传感的吡啶二羧酸（DPA），这是许多致病性孢子形成细菌的主要成分。由于NMOF组合物和形态的可调谐性，本方法应允许不仅合成用目前可用的模板无法获得的有趣的纳米壳，而且还合成用于未来成像、传感和药物递送应用的新型核-壳混合纳米结构。
We describe in this paper a general method for synthesizing a new class of nanocomposites with a nanoscale metal-organic framework (NMOF) core and a silica shell. Silica shells of variable thickness were deposited on the NMOFs that had been surface-modified with polyvinylpyrrolidone (PVP) using a sol-gel procedure. The NMOF core of the nanocomposite could be completely removed (via dissolution) at low pH to afford hollow silica shells with varied thickness and aspect ratios. We also showed that the silica shell of such nanocomposites significantly stabilized the NMOF core against dissolution, thus demonstrating the ability to control the release of metal constituents from such silica-coated NMOFs. The silica shell was further functionalized with a silylated Tb-EDTA monoamide derivative for the luminescence sensing of dipicolinic acid (DPA), which is a major constituent of many pathogenic spore-forming bacteria. Owing to the tunability of NMOF composition and morphology, the present approach should allow for the synthesis of not only interesting nanoshells that are not accessible with presently available templates but also novel core-shell hybrid nanostructures for future imaging, sensing, and drug delivery applications.