EFFECTS OF VARIOUS TACHYKININS ON PITUITARY LH-SECRETION, FEEDING, AND SEXUAL-BEHAVIOR IN THE RAT
EFFECTS OF VARIOUS TACHYKININS ON PITUITARY LH-SECRETION, FEEDING, AND SEXUAL-BEHAVIOR IN THE RAT
复制标题
DOI：
10.1111/j.1749-6632.1991.tb33120.x
复制
发表时间：
1991-09-30
影响因子：
5.2
通讯作者：
KALRA, PS
中科院分区：
文献类型：
--
作者：
KALRA, SP;SAHU, A;KALRA, PS
我们的调查的四个速激肽测试表明，NPK特征性地引起了一系列的生物学效应在雄性和雌性大鼠。NPK通过抑制下丘脑LHRH的释放来抑制垂体LH的释放，可能是通过激活NK-2速激肽受体亚型。然而，NPK也可能在促性腺激素细胞水平上起作用，刺激雄性大鼠LH的释放。中枢注射NPK可迅速阻断性活跃雄性大鼠的交配行为。NPK也抑制进食，但在这种情况下，外周注射比中央注射更有效。两者合计，这些观察结果强烈暗示，NPK可能是下丘脑控制生殖，性和摄食行为的抑制性信使分子。
Our investigations of the four tachykinins tested have shown that NPK characteristically evoked a spectrum of biological effects in male and female rats. NPK suppressed pituitary LH release by inhibiting the release of hypothalamic LHRH, presumably by activation of NK‐2 tachykinin receptor subtypes. However, NPK may also act at the level of gonadotrophs to stimulate LH release in male rats. Central injection of NPK rapidly disrupted copulatory behavior in sexually active male rats. NPK also suppressed feeding, but, in this case, peripheral injections were more effective than central injections. Taken together, these observations strongly imply that NPK may be an inhibitory messenger molecule in the hypothalamic control of reproduction, sexual, and feeding behaviors.