Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines
Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines
复制标题
亚胺对氨基甲酸铵叶立德的非对映选择性转换对映选择性捕获
DOI：
10.1021/ja201589k
复制
发表时间：
2011-06-08
影响因子：
15
通讯作者：
Hu, Wen-Hao
中科院分区：
文献类型：
--
作者：
Jiang, Jun;Xu, Hua-Dong;Hu, Wen-Hao
The diastereoselectively switchable enantioselective trapping of protic carbamate ammonium ylides with imines is reported. The intriguing Rh-2(OAc)(4) and chiral Bronsted acid cocatalyzed three-component Mannich-type reaction of a diazo compound, a carbamate, and an imine provides rapid and efficient access to both syn- and anti-alpha-substituted alpha,beta-diamino acid derivatives with a high level control of chemo-, diastereo-, and enantioselectivity.
