Optical Coherence Tomography Angiography for Diagnosis of Choroidal Neovascularization in Chronic Central Serous Chorioretinopathy after Photodynamic Therapy
Optical Coherence Tomography Angiography for Diagnosis of Choroidal Neovascularization in Chronic Central Serous Chorioretinopathy after Photodynamic Therapy
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DOI：
10.1038/s41598-019-45080-8
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发表时间：
2019-06-21
影响因子：
4.6
通讯作者：
Chen, San-Ni
中科院分区：
文献类型：
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作者：
Wu, Jian-Sheng;Chen, San-Ni
作者评价了既往接受过半剂量光动力学疗法（PDT）治疗的慢性中心性浆液性脉络膜视网膜病变（CSC）（超过3个月）患者中通过光谱域光学相干断层扫描血管造影术（OCTA）检测到的脉络膜新生血管（CNV）比例。所有患者均随访至少12个月。使用光谱域OCT（SD-OCT，RTVue XR; Optovue）获得黄斑血管造影片。CNV定义为外丛状层和Bruch膜之间的外视网膜板层中的血流。比较CNV组与非CNV组的临床特征。纳入61例患者（男51例，女10例）的70只眼。平均年龄46.2岁。平均病程32.9个月。所有患者最初均接受半剂量PDT治疗。11只眼（15.7%）接受了一次以上的PDT治疗。根据OCTA诊断CNV 32/70眼（45.7%）。32只眼中仅6只眼（18.8%）因CNV的渗出活性需要玻璃体内抗血管内皮生长因子（VEGF）治疗。在CNV组中观察到年龄较大（p = 0.059）、PDT斑点尺寸较大（p = 0.024）和中心凹下脉络膜厚度较薄（p = 0.008）。作者得出结论，OCTA揭示了PDT后慢性CSC相关的CNV发生率较高。CNV组患者年龄较大，PDT光斑较大，中心凹下脉络膜厚度较薄。OCTA可作为PDT后慢性CSC中CNV识别的第一步。
The authors evaluated the proportion of choroidal neovascularization (CNV) detected by spectral-domain optical coherence tomography angiography (OCTA) in eyes with chronic central serous chorioretinopathy (CSC) (more than 3 months) with previous treatment via half-dose photodynamic therapy (PDT). All patients were followed up with at least twelve months. Macular angiograms were obtained using spectral-domain OCT (SD-OCT, RTVue XR; Optovue). CNV was defined as flow in the outer retinal slab between the outer plexiform layer and Bruch's membrane. Clinical characteristics were compared between CNV and non-CNV groups. Seventy eyes of 61 patients (51 male and 10 female) were included. The average age was 46.2 years old. The average duration of symptom was 32.9 months. All patients were treated with half-dose PDT initially. Eleven eyes (15.7%) received more than one session of PDT. CNV was diagnosed in 32 of 70 eyes (45.7%) based on OCTA. Only 6 of the 32 eyes (18.8%) needed intravitreal anti- vascular endothelial growth factor (VEGF) therapy for the exudative activity of CNV. Older age (p = 0.059), larger PDT spot size (p = 0.024), and thinner subfoveal choroidal thickness (p = 0.008) were noted in CNV group. The authors conclude that OCTA reveals high rates of CNV associated with chronic CSC after PDT. Patients in the CNV group had older age, larger PDT spot size, and thinner subfoveal choroidal thickness. OCTA may be considered as a first step in identifying CNV in chronic CSC following PDT.