The EORTC CAT Core-The computer adaptive version of the EORTC QLQ-C30 questionnaire
The EORTC CAT Core-The computer adaptive version of the EORTC QLQ-C30 questionnaire
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DOI：
10.1016/j.ejca.2018.04.016
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发表时间：
2018-09-01
影响因子：
8.4
通讯作者：
Groenvold, Mogens
中科院分区：
文献类型：
--
作者：
Petersen, Morten Aa;Aaronson, Neil K.;Groenvold, Mogens
背景资料：为了优化测量精度、与患者的相关性和灵活性，患者报告的结局指标（PROM）最好适合个体患者/研究，同时保持患者/研究之间评分的直接可比性。这可以通过使用试题库和计算机化自适应测试（CAT）来实现。欧洲癌症研究和治疗组织（EORTC）生活质量问卷核心30（QLQ-C30）是癌症研究和临床实践中使用最广泛的PROM之一。在这里，我们提供了一个概述的研究计划，以开发CAT版本的QLQ-C30的14个功能和症状domains.Methods：EORTC生活质量组的战略，开发CAT项目库包括：文献检索，以确定潜在的候选项目，制定新的项目兼容的QLQ-C30的项目风格，专家评估和病人访谈，现场测试和心理测量分析，包括因素分析，项目反应理论校准和测量特性的模拟。此外，软件的设置，运行和评分CAT已经developed.Results：在八轮的数据收集，9782例患者被招募来自12个国家的现场测试。经过四个阶段的开发，在14个领域中总共产生了260个独特的项目。每个试题库由7-34个试题组成。心理测量学评价表明，更高的测量精度和增加的CAT措施相比，QLQ-C30量表的统计能力。使用CAT，样本量要求平均可减少约20-35%而不损失Power.Conclusions：EORTC CAT Core代表了比QLQ-C30更精确、功能更强大和更灵活的测量系统。目前正在一个大型的独立的国际癌症患者样本中进行验证。(C)2018爱思唯尔有限公司版权所有。
Background: To optimise measurement precision, relevance to patients and flexibility, patient-reported outcome measures (PROMs) should ideally be adapted to the individual patient/study while retaining direct comparability of scores across patients/studies. This is achievable using item banks and computerised adaptive tests (CATs). The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) is one of the most widely used PROMs in cancer research and clinical practice. Here we provide an overview of the research program to develop CAT versions of the QLQ-C30's 14 functional and symptom domains.Methods: The EORTC Quality of Life Group's strategy for developing CAT item banks consists of: literature search to identify potential candidate items; formulation of new items compatible with the QLQ-C30 item style; expert evaluations and patient interviews; field-testing and psychometric analyses, including factor analysis, item response theory calibration and simulation of measurement properties. In addition, software for setting up, running and scoring CAT has been developed.Results: Across eight rounds of data collections, 9782 patients were recruited from 12 countries for the field-testing. The four phases of development resulted in a total of 260 unique items across the 14 domains. Each item bank consists of 7-34 items. Psychometric evaluations indicated higher measurement precision and increased statistical power of the CAT measures compared to the QLQ-C30 scales. Using CAT, sample size requirements may be reduced by approximately 20-35% on average without loss of power.Conclusions: The EORTC CAT Core represents a more precise, powerful and flexible measurement system than the QLQ-C30. It is currently being validated in a large independent, international sample of cancer patients. (C) 2018 Elsevier Ltd. All rights reserved.