Multimodal therapy for the treatment of an oncocytoma in the nasal cavity of a cat.
Multimodal therapy for the treatment of an oncocytoma in the nasal cavity of a cat.
复制标题
用于治疗猫鼻腔嗜酸细胞瘤的多模式疗法。
DOI：
10.1111/jsap.12094
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发表时间：
2013
影响因子：
1.6
通讯作者：
Maruo K.
中科院分区：
文献类型：
--
作者：
Mori T;Mishima H;Sakai H;Noguchi S;Maruo K.
一只14岁的雌性绝育杂交猫出现流鼻涕、鼻出血和张口呼吸的临床症状，被送往岐阜大学动物医学中心。颅骨计算机断层扫描 (CT) 扫描显示，双侧鼻腔内有一个肿块，该肿块延伸至右眼眶并损坏了腭骨和筛板；延伸到嗅球。对肿块进行经鼻盲夹活检以进行组织病理学检查。形态学特征、磷钨酸苏木精 (PTAH) 染色模式和免疫组织化学结果（细胞角蛋白阳性和线粒体存在）与嗜酸细胞瘤的诊断一致（Head 等，2003）。治疗开始时静脉注射 15 mg/m2 多柔比星（Adriacin；Kyowa Hakko Kirin），每 3 周静脉注射 100 mg/m2 卡铂（Paraplatin；Bristol-Myers Squibb），同时进行放射治疗，治疗耐受性良好。规定使用正电压辐射，每周 7 次，总共 42Gy。 6周后再次进行CT扫描，结果显示肿瘤消退（图1），临床症状显着减轻，但1周后患者突然死亡。
A 14-year-old female spayed crossbred cat presented to the Animal Medical Center of Gifu University with clinical signs of a nasal discharge, epistaxis and mouth breathing. A computed tomography (CT) scan of the skull revealed a mass affecting the nasal cavities bilaterally, which extended into the right orbit and damaged the palatine bone and cribriform plate; there was extension into the olfactory bulb. A transnasal blind pinch biopsy of the mass was submitted for histopathology. The morphological features, phosphotungstic acid haematoxylin (PTAH) staining pattern and immunohistochemical findings (positivity for cytokeratin and the presence of mitochondria) were consistent with a diagnosis of oncocytoma (Head et al. 2003). Treatment began with alternating doses of 15 mg/m2 doxorubicin (Adriacin; Kyowa Hakko Kirin) intravenously (iv) and 100 mg/m2 carboplatin (Paraplatin; Bristol-Myers Squibb) iv given every 3 weeks with concurrent radiation therapy and was well-tolerated. A total of 42Gy in 7 weekly fractions was prescribed using orthovoltage radiation. A repeat CT scan was performed after 6 weeks and this showed tumour regression (Fig 1) with a significant reduction in the clinical signs, however the patient died suddenly 1 week later.