Individual differences in social network size linked to nucleus accumbens and hippocampal volumes in functional neurological disorder: A pilot study.
Individual differences in social network size linked to nucleus accumbens and hippocampal volumes in functional neurological disorder: A pilot study.
复制标题
功能性神经系统疾病中与伏隔核和海马体积相关的社交网络大小的个体差异：一项试点研究。
DOI：
10.1016/j.jad.2019.07.061
复制
发表时间：
2019
影响因子：
6.6
通讯作者：
Perez,DavidL
中科院分区：
文献类型：
--
作者：
Ospina,JuanPablo;Larson,AnnaG;Jalilianhasanpour,Rozita;Williams,Benjamin;Diez,Ibai;Dhand,Amar;Dickerson,BradfordC;Perez,DavidL
背景在功能性神经（转换）障碍（FND）的生物心理社会学表述中，对社会行为和大脑解剖结构之间的关系知之甚少。我们假设，社会行为将涉及到大脑区域牵连的亲和行为和社会网络的大小将与症状的严重程度和易感的弱点FND.MethodsThis神经影像试点探讨如何社会网络的大小，社会网络指数测量，相关的结构性大脑配置文件在23例运动FND（15名女性和8名男性）。进行FreeSurfer皮质厚度和皮质下体积分析，以校正多重比较。分层分析比较了社交网络规模较小的FND患者与匹配的健康对照组。二次探索性分析，在扩大样本的38 FND患者调查社交网络的大小，风险因素和患者报告的症状severity.ResultsAdjusting年龄和性别之间的关系，神经影像学分析显示，社交网络的大小呈正相关与左丘脑前核和海马体积FND患者分层分析没有显示任何组水平的差异。在FND患者中，社会网络规模与健康相关的生活质量、大学毕业、全职工作和非癫痫发作诊断相关;社会网络规模与终生创伤负担呈负相关，创伤后应激障碍的严重程度和年龄。局限性只有病人-使用了报告的量表，未收集健康受试者的社会网络大小信息。联系网络脑区亲社会行为，并提高FND的生物心理社会概念化。
BackgroundIn the biopsychosocial formulation of functional neurological (conversion) disorder (FND), little is known about relationships between social behavior and brain anatomy. We hypothesized that social behavior would relate to brain areas implicated in affiliative behaviors and that social network size would correlate with symptom severity and predisposing vulnerabilities in FND.MethodsThis neuroimaging pilot probed how social network size, as measured by the Social Network Index, related to structural brain profiles in 23 patients with motor FND (15 woman and 8 men). FreeSurfer cortical thickness and subcortical volumetric analyses were performed correcting for multiple comparisons. Stratified analyses compared FND patients with a low social network size to matched healthy controls. Secondary exploratory analyses in an expanded sample of 38 FND patients investigated relationships between social network size, risk factors and patient-reported symptom severity.ResultsAdjusting for age and gender, neuroimaging analyses showed that social network size positively correlated with left nucleus accumbens and hippocampal volumes in patients with FND; stratified analyses did not show any group-level differences. In individuals with FND, social network size correlated with health-related quality of life, graduating college, working full-time and a non-epileptic seizure diagnosis; social network size inversely related to lifetime trauma burden, post-traumatic stress disorder severity and age.LimitationsOnly patient-reported scales were used and social network size information was not collected for healthy subjects.ConclusionsThis neuroimaging pilot adds to the literature linking affiliation network brain areas to pro-social behaviors and enhances the biopsychosocial conceptualization of FND.