Microsatellite markers and genetic mapping in Plasmodium falciparum
Microsatellite markers and genetic mapping in Plasmodium falciparum
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DOI：
10.1016/s0169-4758(00)01676-8
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发表时间：
2000-07-01
期刊：
影响因子：
--
通讯作者：
Su, XZ
中科院分区：
文献类型：
--
作者：
Ferdig, MT;Su, XZ
全基因组方法正在改变疟疾研究中可以解决的生物学问题的范围。在恶性疟原虫基因组测序提供的丰富背景下，遗传图谱是鉴定寄生虫发育、入侵、传播和耐药性相关基因的有力工具。最近开发的一个高分辨率的恶性疟原虫连锁图谱由数百个微卫星标记组成，将有助于一个综合的基因组方法来了解遗传变异和生物表型之间的关系。在此，Michael Ferdig和Xin-zhuan Su综述了微卫星标记和遗传图谱在基因定位、寄生虫分型和寄生虫种群变化研究中的应用。
Whole-genome methods are changing the scope of biological questions that can be addressed in malaria research. In the rich context provided by Plasmodium falciparum genome sequencing, genetic mapping is a powerful tool for identifying genes involved in parasite development, invasion, transmission and drug resistance. The recent development of a high-resolution P. falciparum linkage map consisting of hundreds of microsatellite markers will facilitate an integrated genomic approach to understanding the relationship between genetic variations and biological phenotypes. Here, Michael Ferdig and Xin-zhuan Su provide an overview for applying microsatellite markers and genetic maps to gene mapping, parasite typing and studies of parasite population changes.