COMPARISON OF EFFECTS OF PHYSICAL EXERCISE, COLD-ACCLIMATION AND REPEATED INJECTIONS OF ISOPRENALINE ON RAT MUSCLE ENZYMES
COMPARISON OF EFFECTS OF PHYSICAL EXERCISE, COLD-ACCLIMATION AND REPEATED INJECTIONS OF ISOPRENALINE ON RAT MUSCLE ENZYMES
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DOI：
10.1111/j.1748-1716.1975.tb10066.x
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
VALTOLA, J
中科院分区：
文献类型：
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作者：
HARRI, MNE;VALTOLA, J
比较了剧烈游泳、冷习服和异丙肾上腺素治疗(每天0.3 mg/kg，共5周)对大鼠心肌和骨骼肌代谢的影响。运动和冷暴露的大鼠比对照组或异丙肾上腺素处理的大鼠体重增加得更少。各治疗组大鼠心脏和肩峰间棕色脂肪组织肥大。只有用异丙肾上腺素处理的动物肾上腺大小增加。冷习服和运动训练增加，异丙肾上腺素处理降低或不影响心肌琥珀酸脱氢酶、核糖酸脱氢酶和柠檬酸合成酶的活性。在骨骼肌中，所有处理都导致这些酶的活性增加。在所分析的厌氧酶中，只有己糖激酶的活性随着所用处理的增加而增加。心脏和骨骼肌的这种增加是相同的，但异丙肾上腺素治疗的增加明显大于训练或冷适应。乳酸脱氢酶和磷酸果糖激酶活性无显著差异。所有处理都提高了耐寒性，但只有游泳运动和冷习服显著提高了运动耐力。结论：儿茶酚胺对肾上腺素能β受体的长时间刺激是引起上述代谢变化的原因。
The metabolic effects on rat cardiac and skeletal muscle of a strenuous program of swimming, of cold acclimation and of isoprenaline treatment (0.3 mg/kg daily for 5 five‐day weeks) were compared. Exercised and cold‐exposed rats gained less body weight than did controls or isoprenaline‐treated rats. In all treated groups the heart and the interscapular brown adipose tissue hypertrophied. The size of the adrenals increased only in isoprenaline‐treated animals. Cold‐acclimation and physical training increased and isoprenaline treatment reduced or did not affect the activities of succinate dehydrogenase, rnalate dehydrogenase and citrate synthase of cardiac muscle. In skeletal muscle all treatments resulted in increased activities of these enzymes. Of the anaerobic enzymes analysed, only the activity of hexokinase increased in response to the treatments used. This increase was the same in cardiac as in skeletal muscle, but it was significantly greater with isoprenaline‐treatment than with training or with cold‐acclimation. The activities of lactate dehydrogenase and phosphofructokinase did not differ significantly. All treatments improved cold resistance, but only swimming exercise and cold acclimation significantly increased tolerance to exercise. It is concluded that prolonged stimulation of adrenergic β‐receptors by catecholamines is responsible for the metabolic changes observed.