Hierarchical coding for sequential task events in the monkey prefrontal cortex
Hierarchical coding for sequential task events in the monkey prefrontal cortex
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DOI：
10.1073/pnas.0802569105
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发表时间：
2008-08-19
影响因子：
11.1
通讯作者：
Duncan, John
中科院分区：
文献类型：
--
作者：
Sigala, Natasha;Kusunoki, Makoto;Duncan, John
额叶在行为的顺序组织中起着关键作用。然而，我们对额叶神经元如何编码结构化任务计划的连续阶段知之甚少。使用相关分析，我们问一个人口的额叶细胞代表一个复杂的顺序任务的多个事件。猴子进行了传统的线索-目标关联任务，具有不同的线索，延迟和目标阶段。在记录的细胞群体中，我们研究了不同任务阶段的活动模式，以及在同一阶段，不同刺激对象的活动模式。结果显示了任务事件的层次表示。对于不同的任务阶段，有不同的，近似正交模式的活动在整个人口。的神经元。每个基本模式的调制编码每个相位内的刺激信息。通过正交编码，额叶可以控制心理程序的离散步骤之间的转换;通过每个步骤内的相关编码，类似的操作可以应用于不同的刺激内容。
The frontal lobes play a key role in sequential organization of behavior. Little is known, however, of the way frontal neurons code successive phases of a structured task plan. Using correlational analysis, we asked how a population of frontal cells represents the multiple events of a complex sequential task. Monkeys performed a conventional cue-target association task, with distinct cue, delay, and target phases. Across the population of recorded cells, we examined patterns of activity for different task phases, and in the same phase, for different stimulus objects. The results show hierarchical representation of task events. For different task phases, there were different, approximately orthogonal patterns of activity across the population. of neurons. Modulations of each basic pattern encoded stimulus information within each phase. By orthogonal coding, the frontal lobe may control transitions between the discrete steps of a mental program; by correlated coding within each step, similar operations may be applied to different stimulus content.