Divergent Associations of Adaptive and Maladaptive Emotion Regulation Strategies With Inflammation
Divergent Associations of Adaptive and Maladaptive Emotion Regulation Strategies With Inflammation
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DOI：
10.1037/a0030068
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发表时间：
2013-07-01
影响因子：
4.2
通讯作者：
Kubzansky, Laura D.
中科院分区：
文献类型：
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作者：
Appleton, Allison A.;Buka, Stephen L.;Kubzansky, Laura D.
目的：最近的研究表明，有效的情绪调节可能会防止患冠心病（CID）的风险，但其机制仍不清楚。调节情绪的策略在如何有效地减轻压力生活经历的潜在毒性作用方面有所不同，因此可能与CID风险有差异。在这项研究中，我们研究了与炎症相关的重新评价和抑制的情绪调节策略，炎症是一种与压力和冠心病相关的生物学状态。我们假设抑制与炎症升高相关，重新评价与炎症水平降低相关。研究方法：我们研究了围产期合作项目参与者的成年后代（n = 379;平均年龄= 42.2岁），这是一个1959-1966年登记的全国孕妇队列。两种情绪调节策略的验证措施进行了检查：重新评价和抑制。炎症以血浆C-反应蛋白（CRP）水平测量。我们拟合多线性回归模型预测CRP，同时控制人口统计学，社会经济学和健康因素，包括抑郁症状;在整个生命过程中测量。结果如下：在控制人口统计学的情况下，再评估的标准差增加1与CRP显著降低相关（B =-0.18，SE = 0.06，p <0.01）。这种关系在生命历程模型中有所减弱，成年体重指数部分解释了这种关联。抑制水平增加1个标准差与CRP显著升高相关（B = 0.21，SE = 0.05，p <0.001），进一步调整协变量后，这种相关性并未显著减弱。结论：适应性情绪调节与较低水平的炎症相关，而适应不良的情绪调节与较高水平的炎症相关。如果这些关联得到前瞻性和实验性研究的证实，这些证据可能会为促进健康和降低心血管风险的干预措施提供新的靶点。
Objective: Recent work suggests effective emotion regulation may protect against risk of developing coronary heart disease (CID), but the mechanisms remain unknown. Strategies for regulating emotions vary in how effectively they mitigate potentially toxic effects of stressful life experiences, and therefore may be differentially associated with CID risk. In this study, we examined the emotion regulation strategies of reappraisal and suppression in relation to inflammation, a biological state associated with both stress and CHD. We hypothesized that suppression would be associated with elevated inflammation and reappraisal would be associated with lower levels of inflammation. Methods: We studied adult offspring (n = 379; mean age = 42.2 years) of Collaborative Perinatal Project participants, a national cohort of pregnant women enrolled in 1959-1966. Validated measures of two emotion regulation strategies were examined: reappraisal and suppression. Inflammation was measured as plasma C-reactive protein (CRP) levels. We fit multiple linear regression models predicting CRP while controlling for demographic, socioeconomic, and health factors, including depressive symptoms;measured across the life course. Results: A 1 standard deviation increase in reappraisal was associated with significantly lower CRP (b = -0.18, SE = 0.06, p < .01) controlling for demographics. This relation was somewhat attenuated in life course models, with adulthood body mass index partially explaining the association. A 1 standard deviation increase in suppression was associated with significantly higher CRP (b = 0.21, SE = 0.05, p < .001), and this association was not substantively attenuated with further covariate adjustment. Conclusion: Adaptive emotion regulation was associated with lower levels of inflammation and maladaptive emotion regulation was associated with higher levels of inflammation. If these associations are confirmed by prospective and experimental studies, such evidence may provide insight into novel targets for interventions to promote health and reduce cardiovascular risk.