Effects of exposure to 0.06 ppm ozone on FEV1 in humans:: A secondary analysis of existing data
Effects of exposure to 0.06 ppm ozone on FEV1 in humans:: A secondary analysis of existing data
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DOI：
10.1289/ehp.11396
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发表时间：
2008-08-01
影响因子：
10.4
通讯作者：
McDonnell, William F.
中科院分区：
文献类型：
--
作者：
Brown, James S.;Bateson, Thomas F.;McDonnell, William F.
背景：臭氧是一种有效的光化学氧化剂，可在急性暴露的人的肺功能中产生短暂的、可逆的减退。最近的一项研究为30名暴露在0.06ppm的O-3下的健康年轻人提供了以前没有的临床数据。这项研究显示0.08ppm对肺功能有显著影响，证实了其他人的发现。然而，暴露于0.06 ppm O-3对肺功能没有显著影响。目的：我们进行这项分析，以重新评估先前暴露于0.06 ppm O-3的志愿者的现有肺功能数据。方法：我们获得了暴露于过滤空气6.6小时、暴露于0.06 ppm或0.08 ppm O-3的所有受试者暴露前和暴露后第一秒用力呼气量(FEV1)的数据。我们使用适合配对比较的标准统计方法，重新分析暴露在0.06PPM O-3相对于过滤空气后的FEV1反应。结果：控制过滤空气反应，30名受试者中有24人经历了O-3诱导的FEV1下降。平均而言，0.06ppmO-3暴露导致FEV1下降2.85%(P 0.002)，这与现有模型预测的FEV1反应一致。尽管平均反应很小，但有两名受试者有10%的FEV1下降。结论：暴露于0.06ppmO-3导致年轻健康成年人的平均FEV1反应在生物学上很小，但在统计学上有非常显著的下降。
BACKGROUND: Ozone is a potent photochemical oxidant that produces transient, reversible decrements in the lung function of acutely exposed individuals. A recent study provided previously unavailable clinical data for 30 healthy young adults exposed to O-3 at 0.06 ppm. That study showed significant effects of 0.08 ppm on lung function, confirming the findings of others. However, exposure to 0.06 PPM O-3 was not reported to significantly affect lung function.OBJECTTVES: We conducted this analysis to reevaluate the existing lung function data of the volunteers previously exposed to 0.06 PPM O-3METHODS: We obtained pre- and postexposure data on forced expiratory volume in 1 see (FEV1) for all subjects who were previously exposed for 6.6 hr to filtered air or to 0.06 ppm or 0.08 ppm O-3. We used standard statistical methods appropriate for paired comparisons to reanalyze FEV1 responses after exposure to 0.06 PPM O-3 relative to filtered air.RESULTS: Controlling for filtered air responses, 24 of the 30 subjects experienced an O-3-induced decrement in FEV1. On average, 0.06 ppm O-3 exposure caused a 2.85% reduction in FEV1 (P 0.002), which was consistent with the predicted FEV1 response from existing models. Although the average response was small, two subjects had > 10% FEV1 decrements.CONCLUSIONS: Exposure to 0.06 ppm O-3 causes a biologically small but highly statistically significant decrease in mean FEV1 responses of young healthy adults.