Single fluoride doses and enamel fluorosis in the rat.
Single fluoride doses and enamel fluorosis in the rat.
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大鼠的单次氟化物剂量和牙釉质氟中毒。
DOI：
10.1159/000260841
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发表时间：
1985
期刊：
影响因子：
4.2
通讯作者：
Whitford,GM
中科院分区：
文献类型：
--
作者：
Angmar-Månsson,B;Whitford,GM
对大鼠单次腹腔注射氟化物（F），15、35或70天后处死。剂量为0、0.75、1.5、4.0、7.0或14.0 mg F/kg。血浆F和钙水平在F给药后24小时内恢复至对照值范围内或附近。在剂量后15天，所有氟注射组的下颌切牙显示出氟中毒的显微放射学证据，并且在氟剂量为4.0 mg/kg或更高的组中，发育中的釉质的磷水平降低。釉质矿化的视觉障碍往往会随着时间的推移而消失，因此，到70天时，14.0 mg/kg组中只有部分矿化的釉质仍受到不利影响。这些结果表明，解释为氟斑牙的釉质矿化障碍，可以发生在没有全身血浆F水平升高。据推测，F从邻近骨骼的逐渐释放在发育中的牙齿附近建立了局部高F水平，并且这些高局部水平足以引起釉质氟中毒。
Single i.p. fluoride (F) injections were given to rats that were sacrificed 15, 35, or 70 days later. The doses were 0, 0.75, 1.5, 4.0, 7.0, or 14.0 mg F/kg. Plasma F and calcium levels had returned to within or near the range of control values within 24 h following the F doses. At 15 days after the doses, the mandibular incisors of all F-injected groups showed microradiographic evidence of fluorosis and the phosphorus levels of the developing enamel were reduced in groups with F doses of 4.0 mg/kg or more. The visual disturbances in enamel mineralization tended to disappear with time so that, by 70 days, only the partially mineralized enamel of the 14.0 mg/kg group remained adversely affected. These findings indicated that disturbances of enamel mineralization interpreted as fluorotic can occur in the absence of elevated systemic plasma F levels. It is hypothesized that the gradual release of F from the adjacent bone establishes locally high F levels in the vicinity of the developing teeth and that these high local levels are sufficient to cause enamel fluorosis.