PET Imaging of the Human Nicotinic Cholinergic Pathway in Atherosclerosis.
PET Imaging of the Human Nicotinic Cholinergic Pathway in Atherosclerosis.
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DOI：
10.1007/s11886-015-0614-8
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发表时间：
2015-08
影响因子：
3.7
通讯作者：
Bucerius J
中科院分区：
文献类型：
--
作者：
Bauwens M;Mottaghy FM;Bucerius J
在过去的几年中，非神经血管烟碱乙酰胆碱受体（nAChR）越来越受到心血管研究的关注，因为它们已知介导尼古丁和亚硝胺（烟草烟雾的组分）对血管系统的有害作用。由于吸烟是动脉粥样硬化发展的主要危险因素，因此很明显，了解nAChR在动脉粥样硬化疾病过程中的病理生理作用以及开发新的诊断和治疗nAChR相关选择变得更加重要。因此，我们简要总结了血管nAChRs在动脉粥样硬化疾病过程中的病理生理作用。我们还提供了一个概述，目前可用的nAChR正电子发射断层扫描（PET）示踪剂和它们的性能在血管nAChR的非侵入性成像，以及潜在的nAChR PET示踪剂，可能是一个选项，在未来的血管nAChR PET成像。
During the past years, non-neuronal vascular nicotinic acetylcholine receptors (nAChRs) increasingly have gained interest in cardiovascular research, as they are known to mediate the deleterious effects of nicotine and nitrosamines, components of tobacco smoke, on the vasculature. Because smoking is a major risk factor for the development of atherosclerosis, it is obvious that understanding the pathophysiologic role of nAChRs in the atherosclerotic disease process, as well as in the development of new diagnostic and therapeutic nAChR-related options, has become more important. Accordingly, we briefly summarize the pathophysiologic role of vascular nAChRs in the atherosclerotic disease process. We also provide an overview of currently available nAChR positron emission tomography (PET) tracers and their performance in the noninvasive imaging of vascular nAChRs, as well as potential nAChR PET tracers that might be an option for vascular nAChR PET imaging in the future.