New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.
New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.
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DOI：
10.1523/jneurosci.3768-08.2008
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发表时间：
2008-11-12
期刊：
影响因子：
--
通讯作者：
Shaw P
中科院分区：
文献类型：
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作者：
Kilduff TS;Lein ES;de la Iglesia H;Sakurai T;Fu YH;Shaw P
了解控制睡眠和觉醒的机制是神经科学的一个主要研究领域。这个小型研讨会回顾强调了一些最近的发展，在基因，分子，细胞和系统水平，已经推进了这一领域。下面讨论的研究利用了从苍蝇到人类的生物体，并集中在睡眠稳态和昼夜节律系统之间的相互作用，参与睡眠时间的昼夜节律钟的基因突变的后果，睡眠剥夺对大脑基因表达的影响，大脑皮层中“睡眠活跃”神经元的发现，下丘脑分泌素/食欲素系统在维持睡眠和觉醒中的作用，以及睡眠和学习之间的相互作用。
Understanding the mechanisms that underlie the control of sleep and wakefulness is a major research area in neuroscience. This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems level that have advanced this field. The studies discussed below utilize organisms ranging from flies to humans and focus on the interaction between the sleep homeostatic and circadian systems, the consequences of mutations in genes involved in the circadian clock on sleep timing, the effects of sleep deprivation on brain gene expression, the discovery of “sleep active” neurons in the cerebral cortex, the role of the hypocretin/orexin system in the maintenance of sleep and wakefulness, and the interaction between sleep and learning.