Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma
Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma
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DOI：
10.1016/j.radonc.2018.08.023
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发表时间：
2018-11-01
影响因子：
5.7
通讯作者：
Sakata, Koh-ichi
中科院分区：
文献类型：
--
作者：
Fukushima, Yuki;Someya, Masanori;Sakata, Koh-ichi
背景和目的：为探讨肿瘤免疫相关蛋白对口咽鳞癌放疗疗效的影响，材料与方法：采用免疫组织化学方法检测92例口咽鳞癌放疗患者p16蛋白及肿瘤免疫相关蛋白的表达。浸润性CD 8阳性细胞丰富的患者的总生存率（OS）显著高于CD 8阳性细胞较少的患者（p = 0.026）。肿瘤细胞中PD-L1表达较高的患者（TC 1-3）的OS（p = 0.019）和无进展生存期（PFS）率（p = 0.032）结局均优于肿瘤细胞中PD-L1表达较低的患者（TC 0）。浸润性免疫细胞中PD-L1高表达的患者（IC 3）的OS（p = 0.009）和PFS（p = 0.011）显著优于PD-L1低表达的患者（IC 0-2）。p16阴性和IC 3的患者显示与p16阳性和IC 0-2的患者相似的OS。结论：除p16表达外，PD-L1在TC和IC中的表达可用于预测OPSCC对放疗的反应。(C)2018由Elsevier B. V.出版
Background and purpose: To investigate influences of proteins involved with tumor immunity on outcomes of radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC).Material and methods: We performed immunohistochemical staining to examine expressions of p16 and proteins involved with tumor immunity in 92 OPSCC patients treated with radiotherapy.Results: Patients with abundant infiltrating CD8-positive cells had the significantly better overall survival (OS) rate than patients with fewer CD8-positive cells (p = 0.026). Patients with higher PD-L1 expression in tumor cells (TC 1-3) had a better outcome than those with low PD-L1 expression in tumor cells (TC 0) for both OS (p = 0.019) and progression-free survival (PFS) rate (p = 0.032). Patients with high PD-L1 expression in infiltrating immune cells (IC 3) showed significantly better OS (p = 0.009) and PFS (p = 0.011) than those with low PD-L1 expression (IC 0-2). Patients with p16-negative and IC 3 showed similar OS to patients with p16-positive and IC 0-2. P16-positive tumors had a significantly higher CD8-positive cell infiltration and PD-L1 expression in tumor cells than p16-negative tumors.Conclusions: In addition to tumor p16 expression, PD-L1 expression in TC and IC can be useful for predicting the response of OPSCC to radiotherapy. (C) 2018 Published by Elsevier B.V.