Systemic and renal effect of intravenous infusion of endothelin-1 in healthy human volunteers.
Systemic and renal effect of intravenous infusion of endothelin-1 in healthy human volunteers.
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静脉输注内皮素-1 对健康志愿者的全身和肾脏影响。
DOI：
10.1152/ajprenal.1994.266.3.f411
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Erling B. Pedersen
中科院分区：
文献类型：
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作者：
S. S. Sørensen;Jens Madsen;Erling B. Pedersen
在 18 名平均年龄为 30 岁的健康人类志愿者中，以 1 pmol.min-1.kg-1 的速度静脉输注内皮素-1 (ET-1) 60 分钟 (n = 9) 或安慰剂 (n = 9) 的效果进行了研究。响应 ET-1 输注，ET-1 浓度从 0.88 +/- 0.27 增加至 10.73 +/- 4.79 (SD) pmol/l。舒张压增加了 7.8%（P < 0.01），心率降低了 14.0%（P < 0.01），而收缩压没有变化。肾血浆流量下降34.7%，肾小球滤过率下降16.1%，肾血管阻力增加66.0%（均P<0.01）。尿钠排泄量减少 57.9%，尿流率减少 40.2%（两者 P < 0.01）。从锂的清除情况来看，我们发现ET-1并没有改变近端肾小管对钠和水的绝对重吸收，但在远端肾小管中钠和水的绝对重吸收显着下降。血管紧张素 II、醛固酮、精氨酸加压素和心房钠尿肽的血浆浓度并未因 ET-1 输注而发生变化。有人认为，在人类某些病理生理条件下发现的血浆浓度的 ET-1 可能会影响肾灌注以及肾钠和水的排泄。
The effect of intravenous infusion of endothelin-1 (ET-1) at a rate of 1 pmol.min-1.kg-1 for 60 min (n = 9) or placebo (n = 9) was investigated in 18 healthy human volunteers with a mean age of 30 yr. In response to ET-1 infusion, concentration of ET-1 increased from 0.88 +/- 0.27 to 10.73 +/- 4.79 (SD) pmol/l. Diastolic blood pressure increased by 7.8% (P < 0.01) and heart rate decreased by 14.0% (P < 0.01), whereas systolic blood pressure did not change. Renal plasma flow decreased by 34.7%, glomerular filtration rate decreased by 16.1%, and renal vascular resistance increased by 66.0% (P < 0.01 all). Urinary sodium excretion decreased by 57.9% and urinary flow rate by 40.2% (P < 0.01 for both). As judged from the clearance of lithium, we found that ET-1 did not change absolute reabsorption of sodium and water in the proximal tubules, but in the distal tubules absolute reabsorption of both sodium and water decreased significantly. Plasma concentrations of angiotensin II, aldosterone, arginine vasopressin, and atrial natriuretic peptide did not change in response to ET-1 infusion. It is suggested that ET-1 at plasma concentrations found in certain pathophysiological conditions in humans may influence renal perfusion and renal sodium and water excretion.