New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
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DOI：
10.1101/2020.05.22.110551
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发表时间：
2020-05
影响因子：
25
通讯作者：
Sarah A. Neely;Jill M Williamson;Anna Klingseisen;Lida Zoupi;J. Early;Anna C. Williams;D. Lyons
中科院分区：
文献类型：
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作者：
Sarah A. Neely;Jill M Williamson;Anna Klingseisen;Lida Zoupi;J. Early;Anna C. Williams;D. Lyons
在脱髓鞘中存活的少突胶质细胞可以重新髓鞘形成，包括多发性硬化症(MS)，但它们如何做到这一点尚不清楚。在这项使用斑马鱼的研究中，我们发现存活下来的少突胶质细胞很少产生新的鞘，并且经常将新的髓鞘错误地定位为神经元细胞体，这也是我们在多发性硬化症中发现的一种病理。相比之下，脱髓鞘后产生的少突胶质细胞产生了丰富的和正确靶向的鞘，这表明它们在Neely等人身上也可能有更好的再生潜力。观察脱髓鞘后不同少突胶质细胞的再生情况。他们发现，新生成的细胞比那些在脱髓鞘中存活的细胞表现出更熟练的再髓鞘形成，这对多发性硬化有一定的影响。
Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes generated after demyelination make abundant and correctly targeted sheaths, indicating that they likely also have a better regenerative potential in MS. Neely et al. investigated the regeneration of different oligodendrocytes after demyelination. They found that newly generated cells exhibit much more proficient remyelination than those that survive demyelination, with implications for MS.