Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae
Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae
复制标题
DOI：
10.1099/vir.0.81546-0
复制
发表时间：
2006-04-01
影响因子：
3.8
通讯作者：
Belsham, GJ
中科院分区：
文献类型：
--
作者：
Chard, LS;Bordeleau, ME;Belsham, GJ
对猪肠道病毒8和猴病毒2的内部核糖体进入位点(IRES)元件进行了特征分析。这些IRES元件与猪病毒1型IRES一样，被发现在功能和结构上与来自黄病毒科成员丙型肝炎病毒的IRES元件有关。部分二级结构预测和功能分析表明，当eIF4G被切割和eIF4A的活性被阻断时，这些IRES元件继续保持活性。
The internal ribosome entry site (IRES) elements from porcine enterovirus 8 and simian virus 2, two members of a proposed new genus within the family Picornaviridae, were characterized. These IRES elements, in common with the porcine teschovirus 1 IRES, were found to be related functionally and structurally to the IRES element from Hepatitis C virus, a member of the family Flaviviridae. Partial secondary structure predictions were derived and functional assays demonstrated that these IRES elements continued to be active when eIF4G was cleaved and when the activity of eIF4A was blocked.