Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records
复制标题
DOI：
10.1016/s0140-6736(20)30360-3
复制
发表时间：
2020-03-07
期刊：
影响因子：
168.9
通讯作者：
Zhang, Yuanzhen
中科院分区：
文献类型：
--
作者：
Chen, Huijun;Guo, Juanjuan;Zhang, Yuanzhen
背景此前关于2019年新型冠状病毒病（COVID-19）引起的肺炎疫情的研究是基于普通人群的信息。关于患有COVID-19肺炎的孕妇的数据有限。本研究旨在评估COVID-19在妊娠期的临床特征和COVID-19感染的宫内垂直传播潜力。方法回顾性分析9例实验室确诊的COVID-19肺炎孕妇的临床记录、实验室检查结果和胸部CT扫描（即用严重急性呼吸综合征冠状病毒2型[SARS-CoV-2]阳性的母体咽拭子样本）在中国武汉市武汉大学中南医院收治的2020年1月20日至1月31日。通过检测羊水、脐带血和新生儿咽拭子样本中SARS-CoV-2的存在来评估宫内垂直传播的证据。母乳样本也被收集和测试后，第一次哺乳期的患者。结果所有9名患者在其妊娠晚期剖腹产。7名患者出现发热。还观察到其他症状，包括咳嗽（9名患者中的4名）、肌痛（3名）、喉咙痛（2名）和不适（2名）。在2例病例中监测了胎儿窘迫。9例患者中有5例淋巴细胞减少（
Background Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection.Methods Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. Breastmilk samples were also collected and tested from patients after the first lactation.Findings All nine patients had a caesarean section in their third trimester. Seven patients presented with a fever. Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. Fetal distress was monitored in two cases. Five of nine patients had lymphopenia (