A high birth weight is associated with increased risk of type 2 diabetes and obesity
A high birth weight is associated with increased risk of type 2 diabetes and obesity
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DOI：
10.1111/ijpo.230
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发表时间：
2015-04-01
影响因子：
3.8
通讯作者：
Gustafsson, J.
中科院分区：
文献类型：
--
作者：
Johnsson, I. W.;Haglund, B.;Gustafsson, J.
背景低出生体重与成人疾病之间的联系是众所周知的。本研究旨在探讨高体重儿是否会增加成人代谢性疾病的风险。方法采用瑞典国家登记系统，对1973年至1982年间759999例瑞典单胎新生儿进行研究。结果出生体重在2~3标准差之间的男性患2型糖尿病的风险增加1.9倍(HR 1.91，95%可信区间1.25~2.90)，出生体重在-2~2标准差之间的男性患2型糖尿病的风险增加5.4倍(HR 5.44，95%CI 2.70~10.96)。女性出生体重2-3SDS和>；3SDS的相对危险度分别为0.60(95%CI 0.40~0.91)和1.71(95%CI 0.85~3.43)。出生体重在2到3个标准差之间的男性患肥胖症的风险增加1.5倍(HR 1.47，95%CI 1.22-1.77)。女性的相应风险增加1.3倍(HR 1.32，95%CI 1.19-1.46)。出生体重超过3个标准差的男性和女性患肥胖症的风险较高，分别为HR 2.46(95%CI 1.63~3.71)和HR 1.85(95%CI 1.44~2.37)。结论出生体重过高，特别是非常高的出生体重，会增加青年男性患2型糖尿病的风险。肥胖的风险随着出生体重的增加而增加。
BackgroundThe association between low birth weight and adult disease is well known. Less is known on long-term effects of high birth weight.ObjectiveThis study aims to investigate whether a high birth weight increases risk for adult metabolic disease.MethodsSwedish term single births, 1973-1982 (n=759999), were studied to age 27.5-37.5 years using Swedish national registers. Hazard ratios (HRs) were calculated in relation to birth weight for type 2 diabetes, obesity, hypertension and dyslipidaemia.ResultsMen with birth weights between 2 and 3 standard deviation score (SDS) had a 1.9-fold increased risk (HR 1.91, 95% confidence interval [CI] 1.25-2.90) of type 2 diabetes, whereas those with birth weights above 3 SDS had a 5.4-fold increased risk (HR 5.44, 95% CI 2.70-10.96) compared to men with birth weights between -2 and 2 SDS. The corresponding HRs for women were 0.60 (95% CI 0.40-0.91) and 1.71 (95% CI 0.85-3.43) for birth weights 2-3 SDS and >3 SDS, respectively. Men with birth weights between 2 and 3 SDS had a 1.5-fold increased risk (HR 1.47, 95% CI 1.22-1.77) of obesity. The corresponding risk for women was 1.3-fold increased (HR 1.32, 95% CI 1.19-1.46). For men and women with birth weights above 3 SDS, the risks of adult obesity were higher, HR 2.46 (95% CI 1.63-3.71) and HR 1.85 (95% CI 1.44-2.37), respectively.ConclusionsA high birth weight, particularly very high, increases the risk of type 2 diabetes in male young adults. The risk of obesity increases with increasing birth weight in both genders.