Evening binge alcohol disrupts cardiovagal tone and baroreflex function during polysomnographic sleep.
Evening binge alcohol disrupts cardiovagal tone and baroreflex function during polysomnographic sleep.
复制标题
晚上暴饮暴食会扰乱多导睡眠期间的心迷走神经张力和压力感受反射功能。
DOI：
10.1093/sleep/zsab130
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发表时间：
2021
期刊：
影响因子：
5.6
通讯作者：
Carter,JasonR
中科院分区：
文献类型：
--
作者：
Greenlund,IanM;Bigalke,JeremyA;Tikkanen,AnneL;Durocher,JohnJ;Smoot,CarlA;Carter,JasonR
研究目的酗酒与心血管疾病风险增加有关。夜间酗酒（即2小时内4-5杯饮料）对睡眠期间HRV和心迷走神经压力反射敏感性（cvBRS）的迷走神经成分的影响在很大程度上仍然不明确。本研究探讨了夜间饮酒对N2期、慢波（SWS）和快眼动（REM）睡眠期间夜间心脏迷走神经张力和压力反射敏感性的影响。我们假设，晚上狂饮会减少HRV和cvBRS在每个睡眠stages. MethodsAfter一个熟悉的夜晚在实验室内，23名参与者进行了检查后，一个晚上的狂饮酒精消费和液体控制（随机，交叉设计）。在这两种情况下，在16名参与者（7名男性，9名女性; 25 ± 1岁）。结果暴饮暴食降低了高频率（HF）和时域成分（即pNN 50和RMSSD）的HRV在N2睡眠阶段，SWS，REM。此外，在N2期（21 ± 3 vs. 15 ± 3 ms/mmHg，p= 0.035）和REM期（15[11-28] vs. 11[9-18] ms/mmHg，p= 0.009），酗酒后cvBRS up-up（迷走神经激活）降低。酗酒使cvBRS下降N2期（迷走神经退缩）（23 ± 2 vs. 14 ± 2 ms/mmHg，p< 0.001），SWS（20[14-30] vs. 14[9-17] ms/mmHg，p= 0.022）和REM（14[11-24] vs. 10[7-15] ms/mmHg，p= 0.006）.结论：在几乎所有的睡眠阶段，晚上饮酒过量都会破坏心脏迷走神经张力和压力感受性反射功能。这些发现为狂饮和酒精滥用对心血管风险的潜在作用提供了机制性的见解。临床试验详细信息狂饮者的酒精和神经心血管控制，www.clinicaltrials.gov/ct2/show/NCT03567434，NCT 03567434。
Study ObjectivesBinge alcohol consumption is associated with increased cardiovascular risk. The effects of evening binge alcohol consumption (i.e. 4–5 beverages within 2 h) on the vagal components of HRV and cardiovagal baroreflex sensitivity (cvBRS) during sleep remain largely equivocal. The present study examined the effects of evening binge alcohol consumption on nocturnal cardiac vagal tone and baroreflex sensitivity during stage N2, slow wave (SWS), and rapid eye movement (REM) sleep. We hypothesized that evening binge drinking would reduce HRV and cvBRS in each sleep stage.MethodsFollowing a familiarization night within the laboratory, twenty-three participants were examined following a night of binge alcohol consumption and a fluid control (randomized, crossover design). A quality nocturnal beat-to-beat blood pressure signal was obtained in both conditions in 16 participants (seven men, nine women; 25 ± 1 years).ResultsBinge drinking reduced both the high frequency (HF) and time-domain components (i.e. pNN50 and RMSSD) of HRV in stage N2 sleep, SWS, and REM. In addition, cvBRS up-up (vagal activation) was reduced following binge alcohol consumption in stage N2 (21 ± 3 vs. 15 ± 3 ms/mmHg,p= 0.035) and REM (15[11–28] vs. 11[9–18] ms/mmHg,p= 0.009). Binge alcohol consumption reduced cvBRS down-down (vagal withdrawal) in stage N2 (23 ± 2 vs. 14 ± 2 ms/mmHg,p< 0.001), SWS (20[14–30] vs. 14[9–17] ms/mmHg,p= 0.022), and REM (14[11–24] vs. 10[7–15] ms/mmHg,p= 0.006).ConclusionsEvening binge alcohol consumption disrupts cardiac vagal tone and baroreflex function during nearly all sleep stages. These findings provide mechanistic insight into the potential role of binge drinking and alcohol abuse on cardiovascular risk.Clinical Trials DetailsAlcohol and Neural Cardiovascular Control in Binge Drinkers, www.clinicaltrials.gov/ct2/show/NCT03567434, NCT03567434.