Mechanism of joint sparing in a patient with unilateral psoriatic arthritis and a longstanding hemiplegia.
Mechanism of joint sparing in a patient with unilateral psoriatic arthritis and a longstanding hemiplegia.
复制标题
单侧银屑病关节炎和长期偏瘫患者的关节保留机制。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
O. FitzGerald
中科院分区：
文献类型：
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作者：
D. Veale;M. Farrell;O. FitzGerald
报道一例长期偏瘫的 59 岁女性，仅出现单侧银屑病关节炎和非偏瘫侧单侧银屑病。研究显示红细胞沉降率为 58 mm/h，血清和滑液 (SF) 中所有类别的类风湿因子均为阴性。尽管偏瘫侧没有临床受累，但两个膝关节均显示有炎症浸润。此外，虽然在两个滑膜样本中都证明了神经丝和 P 物质 (SP) 免疫反应性，但临床涉及的滑膜中存在的 SP 明显较少。最后，仅在临床涉及的膝关节中 SP 和 IL1 β 的 SF 水平升高。
The case of a 59-year-old female with a longstanding hemiplegia who developed unilateral psoriatic arthritis and unilateral psoriasis on the non-hemiplegic side only is reported. Investigations showed an erythrocyte sedimentation rate of 58 mm/h, with all classes of rheumatoid factor negative in serum and synovial fluid (SF). An inflammatory infiltrate was demonstrated in both knee joints despite the absence of clinical involvement on the hemiplegic side. In addition, while neurofilament and substance P (SP) immunoreactivity was demonstrated in both synovial specimens, conspicuously less SP was present in the clinically involved synovial membrane. Finally, SF levels of SP and IL1 beta were raised in the clinically involved knee only.