Interaction between nitric oxide and thromboxane A2 in the regulation of the resting cerebrovascular tone.

Interaction between nitric oxide and thromboxane A2 in the regulation of the resting cerebrovascular tone.
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一氧化氮和血栓素 A2 在静息脑血管张力调节中的相互作用。

DOI:
10.1007/978-1-4615-4717-4_45
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发表时间:
1999
影响因子:
--
通讯作者:
M. Wahl
M. Wahl
中科院分区:
医学4区
文献类型:
--
作者:
Z. Benyó;C. Görlach;M. Wahl

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一氧化氮(NO)在脑血流量(CBF)的调节中起重要作用(综述参见:Faraci和Heistad,1998)。L-精氨酸-NO途径的抑制导致脑血管收缩和CBF的减少,表明NO的基础释放在脑血管床中提供了静息松弛张力(综述参见:Iadecola等人,1994年)。这种基础NO产生的作用通常被认为是对平滑肌的直接松弛作用。NO可能通过调节前列腺素类合成来调节静息脑血管张力的可能性至今尚未研究。
Nitric oxide (NO) plays an important role in the regulation of the cerebral blood flow (CBF) (for review see: Faraci and Heistad, 1998). Inhibition of the L-arginine—NO pathway results in cerebral vasoconstriction and reduction of the CBF, indicating that the basal release of NO provides a resting relaxant tone in the cerebrovascular bed (for review see: Iadecola et al., 1994). This effect of basal NO production has generally been regarded as a direct relaxant action on the smooth muscle. The possibility that NO may regulate the resting cerebrovascular tone by modulation of the prostanoid synthesis has not been investigated to date.
其心血管作用的证据表明,7-硝基吲唑可能在体内抑制内皮一氧化氮合酶。
DOI: 10.1016/0014-2999(96)00106-9
发表时间: 1996
影响因子: 5
作者:
Zagvazdin,Y;Sancesario,G;Wang,YX;Share,L;Fitzgerald,ME;Reiner,A
通讯作者: Reiner,A
DOI: 10.1073/pnas.95.9.4888
发表时间: 1998-04-28
影响因子: 11.1
作者:
Wang, GR;Zhu, Y;Mendelsohn, ME
通讯作者: Mendelsohn, ME