The acyl-CoA synthetase inhibitor triacsin C enhanced eicosanoid release in leukocytes.
The acyl-CoA synthetase inhibitor triacsin C enhanced eicosanoid release in leukocytes.
复制标题
酰基辅酶A合成酶抑制剂三十二烷酸C可增强白细胞中类二十烷酸的释放。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
S. Ōmura
中科院分区：
文献类型：
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作者：
S. Oh‐ishi;K. Yamaki;M. Abe;H. Tomoda;S. Ōmura
先前报道 Triacsin C 可抑制长链酰基辅酶 A 合成酶并减少大鼠中性粒细胞中酰基辅酶 A 的产生，且呈剂量和时间依赖性。我们发现，与 Triacsin C 预孵育可抑制标记的花生四烯酸掺入大鼠中性粒细胞。此外，当用 Ca 离子载体 A23187 刺激经 Triacsin C 处理的中性粒细胞时，它们会向培养基中释放更多量的类二十烷酸。这些结果表明三十二烷酸 C 抑制花生四烯酸的酰化，从而导致其代谢物增加。
Triacsin C was previously reported to inhibit long-chain acyl-CoA synthetase and to reduce the production of acyl-CoA in rat neutrophils dose- and time-dependently. We found that preincubation with triacsin C inhibited the incorporation of labeled arachidonic acid into rat neutrophils. Furthermore, when triacsin C-treated neutrophils were stimulated with the Ca-ionophore A23187, they released an increased amount of eicosanoids into the culture medium. These results indicate that triacsin C suppressed acylation of arachidonic acid, which resulted in an increase in its metabolites.