The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.
The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.
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DOI：
10.1371/journal.pone.0267913
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
系统性红斑狼疮是一种以自身抗体、肾脏和皮肤疾病以及免疫复合物形成为特征的慢性疾病。新出现的证据表明，DNA修复异常是狼疮发展的一个潜在机制。我们以前表明，POLBY 265 C/C突变，这导致一个异常的免疫库的发展，导致狼疮样疾病的小鼠。为了解决造血区室是否足以用于狼疮发展，我们将来自POLBY 265 C/C和POLB+/+的骨髓细胞移植到野生型同类小鼠中。只有移植了POLBY 265 C/C骨髓的小鼠才会产生高水平的抗核抗体和肾脏疾病。总之，我们表明从POLBY 265 C/C小鼠收获的造血区室足以发展自身免疫性疾病。
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We previously showed that the POLBY265C/C mutation, which results in development of an aberrant immune repertoire, leads to lupus-like disease in mice. To address whether the hematopoietic compartment is sufficient for lupus development, we transplanted bone marrow cells from POLBY265C/C and POLB+/+ into wild-type congenic mice. Only mice transplanted with the POLBY265C/C bone marrow develop high levels of antinuclear antibodies and renal disease. In conclusion, we show that the hematopoietic compartment harvested from the POLBY265C/C mice is sufficient for development of autoimmune disease.
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影响因子：
8.8
作者：
Senejani AG;Liu Y;Kidane D;Maher SE;Zeiss CJ;Park HJ;Kashgarian M;McNiff JM;Zelterman D;Bothwell AL;Sweasy JB
通讯作者：
Sweasy JB
影响因子：
--
作者：
Petri, Michelle;Orbai, Ana-Maria;Alarcon, Graciela S.;Gordon, Caroline;Merrill, Joan T.;Fortin, Paul R.;Bruce, Ian N.;Isenberg, David;Wallace, Daniel J.;Nived, Ola;Sturfelt, Gunnar;Ramsey-Goldman, Rosalind;Bae, Sang-Cheol;Hanly, John G.;Sanchez-Guerrero, Jorge;Clarke, Ann;Aranow, Cynthia;Manzi, Susan;Urowitz, Murray;Gladman, Dafna;Kalunian, Kenneth;Costner, Melissa;Werth, Victoria P.;Zoma, Asad;Bernatsky, Sasha;Ruiz-Irastorza, Guillermo;Khamashta, Munther A.;Jacobsen, Soren;Buyon, Jill P.;Maddison, Peter;Dooley, Mary Anne;van vollenhoven, Ronald F.;Ginzler, Ellen;Stoll, Thomas;Peschken, Christine;Jorizzo, Joseph L.;Callen, Jeffrey P.;Lim, S. Sam;Fessler, Barri J.;Inanc, Murat;Kamen, Diane L.;Rahman, Anisur;Steinsson, Kristjan;Franks, Andrew G., Jr.;Sigler, Lisa;Hameed, Suhail;Fang, Hong;Ngoc Pham;Brey, Robin;Weisman, Michael H.;McGwin, Gerald, Jr.;Magder, Laurence S.
通讯作者：
Magder, Laurence S.
影响因子：
3.8
作者：
Prasad R;Çağlayan M;Dai DP;Nadalutti CA;Zhao ML;Gassman NR;Janoshazi AK;Stefanick DF;Horton JK;Krasich R;Longley MJ;Copeland WC;Griffith JD;Wilson SH
通讯作者：
Wilson SH
影响因子：
3.8
作者：
Chan MK;Ocampo-Hafalla MT;Vartanian V;Jaruga P;Kirkali G;Koenig KL;Brown S;Lloyd RS;Dizdaroglu M;Teebor GW
通讯作者：
Teebor GW
影响因子：
14.9
作者：
Ray S;Breuer G;DeVeaux M;Zelterman D;Bindra R;Sweasy JB
通讯作者：
Sweasy JB