Where is human V4? Predicting the location of hV4 and VO1 from cortical folding.
Where is human V4? Predicting the location of hV4 and VO1 from cortical folding.
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DOI：
10.1093/cercor/bht092
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发表时间：
2014-09
期刊：
影响因子：
3.7
通讯作者：
Nathan Witthoft;M. Nguyen;G. Golarai;Karen F. LaRocque;A. Liberman;Mary E. Smith;K. Grill-Spector
中科院分区：
文献类型：
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作者：
Nathan Witthoft;M. Nguyen;G. Golarai;Karen F. LaRocque;A. Liberman;Mary E. Smith;K. Grill-Spector
皮质折叠与人脑主要感觉区域的位置之间存在密切关系，这一点已得到充分证实。然而，尚不清楚在感觉处理的较高阶段是否发现功能反应和总体解剖学之间的耦合。我们研究了皮质折叠与视网膜专题图 hV4 和 VO1 位置之间的关系，它们是人类腹侧视觉处理流的中间阶段。我们的数据显示，在解剖学方面，hV4 和 VO1 内的偏心图排列一致，因此，尽管图尺寸和皮质折叠存在个体差异，但 hV4/VO1 边界在后横副沟 (ptCoS) 中一致存在。了解这种关系使我们能够仅使用他们的解剖结构来预测一组单独个体的视觉区域 hV4 和 VO1 的位置，准确率 >85%。这些发现对于理解皮质折叠和功能图之间的关系以及仅从解剖标志定义视觉区域具有重要意义。
A strong relationship between cortical folding and the location of primary sensory areas in the human brain is well established. However, it is unknown if coupling between functional responses and gross anatomy is found at higher stages of sensory processing. We examined the relationship between cortical folding and the location of the retinotopic maps hV4 and VO1, which are intermediate stages in the human ventral visual processing stream. Our data show a consistent arrangement of the eccentricity maps within hV4 and VO1 with respect to anatomy, with the consequence that the hV4/VO1 boundary is found consistently in the posterior transverse collateral sulcus (ptCoS) despite individual variability in map size and cortical folding. Understanding this relationship allowed us to predict the location of visual areas hV4 and VO1 in a separate set of individuals, using only their anatomies, with >85% accuracy. These findings have important implications for understanding the relation between cortical folding and functional maps as well as for defining visual areas from anatomical landmarks alone.