Involvement of CB1 cannabinoid receptors in emotional behaviour
Involvement of CB1 cannabinoid receptors in emotional behaviour
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DOI：
10.1007/s00213-001-0946-5
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发表时间：
2002-02-01
影响因子：
3.4
通讯作者：
Valverde, O
中科院分区：
文献类型：
--
作者：
Martin, M;Ledent, C;Valverde, O
基本原理：通过CB I大麻素受体起作用的内源性和外源性大麻素涉及多种行为和神经内分泌功能的控制，包括情绪反应以及学习和记忆过程。最近，已经产生了CB I大麻素受体缺陷的敲除小鼠，并且这些动物产生了评价内源性大麻素系统的神经生理学的极好工具。目的：确定CB I大麻素受体在几种情绪相关行为反应中的作用，包括攻击性，焦虑，抑郁和学习模型。使用CB I敲除小鼠。研究方法：我们评估了CB I基因敲除小鼠和野生型对照在不同行为模式下的自发反应，包括亮/暗箱、慢性不可预测的轻度应激、居民-入侵者测试和主动回避模式。结果如下：我们的研究结果表明，CB I基因敲除小鼠在居民入侵者测试中测量的攻击性反应和在亮/暗箱中的致焦虑样反应增加。此外，在CB 1基因敲除小鼠中观察到，在慢性不可预测的轻度应激过程中，表现出抑郁样反应的敏感性更高，这表明这些动物出现享乐缺乏状态的易感性增加。最后，CB I基因敲除小鼠显示出在主动回避模型中产生的条件反应的显著增加，表明学习和记忆过程的改善。结论：总之，这些发现表明，内源性大麻素通过激活CB I受体参与情绪行为的控制，并参与学习和记忆的生理过程。
Rationale: Endogenous and exogenous cannabinoids acting through the CB I cannabinoid receptors are implicated in the control of a variety of behavioural and neuroendocrine functions, including emotional responses, and learning and memory processes. Recently, knockout mice deficient in the CB I cannabinoid receptor have been generated, and these animals result in an excellent tool to evaluate the neurophysiology of the endogenous cannabinoid system. Objectives: To establish the role of the CB I cannabinoid receptor in several emotional-related behavioural responses, including aggressiveness, anxiety, depression and learning models. using CB I knockout mice. Methods: We evaluated the spontaneous responses of CB I knockout mice and wild-type controls under different behavioural paradigms, including the light/dark box, the chronic unpredictable mild stress, the resident-intruder test and the active avoidance paradigm. Results: Our findings showed that CB I knockout mice presented an increase in the aggressive response measured in the resident-intruder test and an anxiogenic-like response in the light/dark box. Furthermore, a higher sensitivity to exhibit depressive-like responses in the chronic unpredictable mild stress procedure was observed in CB1 knockout mice, suggesting an increased susceptibility to develop an anhedonic state in these animals. Finally, CB I knockout mice showed a significant increase in the conditioned responses produced in the active avoidance model, suggesting an improvement of learning and memory processes. Conclusions: Taken together these findings demonstrate that endogenous cannabinoids through the activation of CB I receptors are implicated in the control of emotional behaviour and participate in the physiological processes of learning and memory.