Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG 7142.
Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG 7142.
复制标题
致焦虑的 β-咔啉 FG 7142 选择性增加前额皮质中的多巴胺代谢。
DOI：
10.1016/0006-2952(85)90708-7
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发表时间：
1985
影响因子：
5.8
通讯作者：
Roth,RH
中科院分区：
文献类型：
--
作者：
Tam,SY;Roth,RH
材料和方法 体重 350-375 g 的雄性 Sprague-Dawley 大鼠获自 Camm（新泽西州韦恩）。 FG 7142，由 Drs 提供。 C. Braestrup 和 EN Petersen，A/S Ferrosan，丹麦，将每 3.5 毫升一滴 Tween 80 悬浮在蒸馏水中。对悬浮液进行广泛超声处理，并以 2 ml/kg 的体积给药，在 FG 7142 给药后 30 分钟，腹膜内处死动物，并如前所述解剖出各个脑区域[11]。组织 DA 和 3, 4-二羟基苯乙酸 1595
MATERIALS AND METHODS Male Sprague-Dawley rats weighing 350-375 g were obtained from Camm (Wayne, New Jersey). FG 7142, provided by Drs. C. Braestrup and EN Petersen, A/S Ferrosan, Denmark, was suspended in distilled water with one drop of Tween 80 per 3.5 ml. The suspension was extensively sonicated and admini~ cered in a volume of 2 ml/kg, ip Animals were killed 30 min after FG 7142 administration, and various brain regions were dissected out as previously described [11]. Tissue DA and 3, 4-dihydroxy-phenylacetic 1595